FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2057682244> ?p ?o ?g. }

• W2057682244 endingPage "72" @default.
• W2057682244 startingPage "63" @default.
• W2057682244 abstract "Dextromethorphan (DM) is a dextrorotary morphinan and a widely used component of cough medicine. Relatively high doses of DM in combination with quinidine are used for the treatment of mood disorders for patients with multiple sclerosis (MS). However, at lower doses, morphinans exert anti-inflammatory activities through the inhibition of NOX2-dependent superoxide production in activated microglia. Here we investigated the effects of high (10 mg/kg, i.p., DM-10) and low (0.1 mg/kg, i.p., DM-0.1) doses of DM on the development and progression of mouse experimental autoimmune encephalomyelitis (EAE), an animal model of MS. We found no protection by high dose DM treatment. Interestingly, a minor late attenuation by low dose DM treatment was seen in severe EAE that was characterized by a chronic disease course and a massive spinal cord infiltration of CD45(+) cells including T-lymphocytes, macrophages and neutrophils. Furthermore, in a less severe form of EAE, where lower levels of CD4(+) and CD8(+) T-cells, Iba1(+) microglia/macrophages and no significant infiltration of neutrophils were seen in the spinal cord, the treatment with DM-0.1 was remarkably more beneficial. The effect was the most significant at the peak of disease and was associated with an inhibition of NOX2 expression and a decrease in infiltration of monocytes and lymphocytes into the spinal cord. In addition, chronic treatment with low dose DM resulted in decreased demyelination and reduced axonal loss in the lumbar spinal cord. Our study is the first report to show that low dose DM is effective in treating EAE of moderate severity. Our findings reveal that low dose morphinan DM treatment may represent a new promising protective strategy for treating MS." @default.
• W2057682244 created "2016-06-24" @default.
• W2057682244 creator A5001959448 @default.
• W2057682244 creator A5071852918 @default.
• W2057682244 creator A5072379424 @default.
• W2057682244 creator A5075667146 @default.
• W2057682244 creator A5082374858 @default.
• W2057682244 creator A5091386381 @default.
• W2057682244 date "2011-10-01" @default.
• W2057682244 modified "2023-10-18" @default.
• W2057682244 title "Low dose dextromethorphan attenuates moderate experimental autoimmune encephalomyelitis by inhibiting NOX2 and reducing peripheral immune cells infiltration in the spinal cord" @default.
• W2057682244 cites W1510081630 @default.
• W2057682244 cites W1558962636 @default.
• W2057682244 cites W1968666033 @default.
• W2057682244 cites W1970910000 @default.
• W2057682244 cites W1979328277 @default.
• W2057682244 cites W1983752854 @default.
• W2057682244 cites W1986195187 @default.
• W2057682244 cites W1991589744 @default.
• W2057682244 cites W1995317457 @default.
• W2057682244 cites W2001442825 @default.
• W2057682244 cites W2004552736 @default.
• W2057682244 cites W2017360920 @default.
• W2057682244 cites W2019079031 @default.
• W2057682244 cites W2019291478 @default.
• W2057682244 cites W2023751022 @default.
• W2057682244 cites W2027988135 @default.
• W2057682244 cites W2028935955 @default.
• W2057682244 cites W2041071307 @default.
• W2057682244 cites W2044278619 @default.
• W2057682244 cites W2046916629 @default.
• W2057682244 cites W2048534910 @default.
• W2057682244 cites W2056311398 @default.
• W2057682244 cites W2068853695 @default.
• W2057682244 cites W2071205488 @default.
• W2057682244 cites W2083218881 @default.
• W2057682244 cites W2085128107 @default.
• W2057682244 cites W2101958789 @default.
• W2057682244 cites W2106455538 @default.
• W2057682244 cites W2107095021 @default.
• W2057682244 cites W2107277218 @default.
• W2057682244 cites W2108335498 @default.
• W2057682244 cites W2123131795 @default.
• W2057682244 cites W2123766360 @default.
• W2057682244 cites W2128780557 @default.
• W2057682244 cites W2133604289 @default.
• W2057682244 cites W2141664407 @default.
• W2057682244 cites W2151836923 @default.
• W2057682244 cites W2156608053 @default.
• W2057682244 cites W2158019652 @default.
• W2057682244 cites W2158427090 @default.
• W2057682244 cites W2158512964 @default.
• W2057682244 doi "https://doi.org/10.1016/j.nbd.2011.06.004" @default.
• W2057682244 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3153572" @default.
• W2057682244 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21704706" @default.
• W2057682244 hasPublicationYear "2011" @default.
• W2057682244 type Work @default.
• W2057682244 sameAs 2057682244 @default.
• W2057682244 citedByCount "44" @default.
• W2057682244 countsByYear W20576822442012 @default.
• W2057682244 countsByYear W20576822442013 @default.
• W2057682244 countsByYear W20576822442014 @default.
• W2057682244 countsByYear W20576822442015 @default.
• W2057682244 countsByYear W20576822442016 @default.
• W2057682244 countsByYear W20576822442017 @default.
• W2057682244 countsByYear W20576822442018 @default.
• W2057682244 countsByYear W20576822442019 @default.
• W2057682244 countsByYear W20576822442020 @default.
• W2057682244 countsByYear W20576822442021 @default.
• W2057682244 countsByYear W20576822442022 @default.
• W2057682244 countsByYear W20576822442023 @default.
• W2057682244 crossrefType "journal-article" @default.
• W2057682244 hasAuthorship W2057682244A5001959448 @default.
• W2057682244 hasAuthorship W2057682244A5071852918 @default.
• W2057682244 hasAuthorship W2057682244A5072379424 @default.
• W2057682244 hasAuthorship W2057682244A5075667146 @default.
• W2057682244 hasAuthorship W2057682244A5082374858 @default.
• W2057682244 hasAuthorship W2057682244A5091386381 @default.
• W2057682244 hasBestOaLocation W20576822442 @default.
• W2057682244 hasConcept C118552586 @default.
• W2057682244 hasConcept C121332964 @default.
• W2057682244 hasConcept C126322002 @default.
• W2057682244 hasConcept C134018914 @default.
• W2057682244 hasConcept C153400128 @default.
• W2057682244 hasConcept C203014093 @default.
• W2057682244 hasConcept C2776914184 @default.
• W2057682244 hasConcept C2777899865 @default.
• W2057682244 hasConcept C2778486448 @default.
• W2057682244 hasConcept C2779830541 @default.
• W2057682244 hasConcept C2780640218 @default.
• W2057682244 hasConcept C2780775167 @default.
• W2057682244 hasConcept C2781245242 @default.
• W2057682244 hasConcept C71924100 @default.
• W2057682244 hasConcept C8891405 @default.
• W2057682244 hasConcept C97355855 @default.
• W2057682244 hasConcept C98274493 @default.
• W2057682244 hasConceptScore W2057682244C118552586 @default.
• W2057682244 hasConceptScore W2057682244C121332964 @default.

• next