Matches in SemOpenAlex for { <https://semopenalex.org/work/W2057685909> ?p ?o ?g. }
- W2057685909 endingPage "185" @default.
- W2057685909 startingPage "177" @default.
- W2057685909 abstract "Adult malignant brainstem gliomas (BSGs) are poorly characterized due to their relative rarity. We have examined histopathologically confirmed cases of adult malignant BSGs to better characterize the patient and tumor features and outcomes, including the natural history, presentation, imaging, molecular characteristics, prognostic factors, and appropriate treatments. A total of 34 patients were identified, consisting of 22 anaplastic astrocytomas (AAs) and 12 glioblastomas (GBMs). The overall median survival for all patients was 25.8 months, with patients having GBMs experiencing significantly worse survival (12.1 vs. 77.0 months, p = 0.0011). The majority of tumors revealed immunoreactivity for EGFR (93.3 %) and MGMT (64.7 %). Most tumors also exhibited chromosomal abnormalities affecting the loci of epidermal growth factor receptor (92.9 %), MET (100 %), PTEN (61.5 %), and 9p21 (80 %). AAs more commonly appeared diffusely enhancing (50.0 vs. 27.3 %) or diffusely nonenhancing (25.0 vs. 0.0 %), while GBMs were more likely to exhibit focal enhancement (54.6 vs. 10.0 %). Multivariate analysis revealed confirmed histopathology for GBM to significantly affect survival (HR 4.80; 95 % CI 1.86-12.4; p = 0.0012). In conclusion, adult malignant BSGs have an overall poor prognosis, with GBM tumors faring significantly worse than AAs. As AAs and GBMs have differing imaging characteristics, tissue diagnosis may be necessary to accurately determine patient prognosis and identify molecular characteristics which may aid in the treatment of these aggressive tumors." @default.
- W2057685909 created "2016-06-24" @default.
- W2057685909 creator A5026450511 @default.
- W2057685909 creator A5031831436 @default.
- W2057685909 creator A5044465742 @default.
- W2057685909 creator A5060265614 @default.
- W2057685909 creator A5070064282 @default.
- W2057685909 creator A5073862375 @default.
- W2057685909 creator A5083472710 @default.
- W2057685909 creator A5088379828 @default.
- W2057685909 date "2014-05-17" @default.
- W2057685909 modified "2023-10-16" @default.
- W2057685909 title "Malignant brainstem gliomas in adults: clinicopathological characteristics and prognostic factors" @default.
- W2057685909 cites W1887747927 @default.
- W2057685909 cites W1969104636 @default.
- W2057685909 cites W1991266196 @default.
- W2057685909 cites W2019178073 @default.
- W2057685909 cites W2019524227 @default.
- W2057685909 cites W2025183726 @default.
- W2057685909 cites W2030699925 @default.
- W2057685909 cites W2043593133 @default.
- W2057685909 cites W2064214863 @default.
- W2057685909 cites W2066343654 @default.
- W2057685909 cites W2070736047 @default.
- W2057685909 cites W2073849733 @default.
- W2057685909 cites W2085054587 @default.
- W2057685909 cites W2086489030 @default.
- W2057685909 cites W2096287682 @default.
- W2057685909 cites W2105100844 @default.
- W2057685909 cites W2106140351 @default.
- W2057685909 cites W2121749405 @default.
- W2057685909 cites W2125284356 @default.
- W2057685909 cites W2128118063 @default.
- W2057685909 cites W2137401200 @default.
- W2057685909 cites W2158969219 @default.
- W2057685909 cites W2163910135 @default.
- W2057685909 cites W2164953032 @default.
- W2057685909 cites W2165438710 @default.
- W2057685909 cites W2322283828 @default.
- W2057685909 cites W2414648446 @default.
- W2057685909 doi "https://doi.org/10.1007/s11060-014-1471-9" @default.
- W2057685909 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4510613" @default.
- W2057685909 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24838419" @default.
- W2057685909 hasPublicationYear "2014" @default.
- W2057685909 type Work @default.
- W2057685909 sameAs 2057685909 @default.
- W2057685909 citedByCount "33" @default.
- W2057685909 countsByYear W20576859092015 @default.
- W2057685909 countsByYear W20576859092016 @default.
- W2057685909 countsByYear W20576859092017 @default.
- W2057685909 countsByYear W20576859092018 @default.
- W2057685909 countsByYear W20576859092019 @default.
- W2057685909 countsByYear W20576859092020 @default.
- W2057685909 countsByYear W20576859092021 @default.
- W2057685909 countsByYear W20576859092022 @default.
- W2057685909 countsByYear W20576859092023 @default.
- W2057685909 crossrefType "journal-article" @default.
- W2057685909 hasAuthorship W2057685909A5026450511 @default.
- W2057685909 hasAuthorship W2057685909A5031831436 @default.
- W2057685909 hasAuthorship W2057685909A5044465742 @default.
- W2057685909 hasAuthorship W2057685909A5060265614 @default.
- W2057685909 hasAuthorship W2057685909A5070064282 @default.
- W2057685909 hasAuthorship W2057685909A5073862375 @default.
- W2057685909 hasAuthorship W2057685909A5083472710 @default.
- W2057685909 hasAuthorship W2057685909A5088379828 @default.
- W2057685909 hasBestOaLocation W20576859092 @default.
- W2057685909 hasConcept C126322002 @default.
- W2057685909 hasConcept C142724271 @default.
- W2057685909 hasConcept C143998085 @default.
- W2057685909 hasConcept C190283241 @default.
- W2057685909 hasConcept C2777609662 @default.
- W2057685909 hasConcept C2778227246 @default.
- W2057685909 hasConcept C2778880634 @default.
- W2057685909 hasConcept C2779083369 @default.
- W2057685909 hasConcept C38180746 @default.
- W2057685909 hasConcept C502942594 @default.
- W2057685909 hasConcept C544855455 @default.
- W2057685909 hasConcept C551621295 @default.
- W2057685909 hasConcept C55493867 @default.
- W2057685909 hasConcept C57742111 @default.
- W2057685909 hasConcept C71924100 @default.
- W2057685909 hasConcept C86554907 @default.
- W2057685909 hasConcept C86803240 @default.
- W2057685909 hasConceptScore W2057685909C126322002 @default.
- W2057685909 hasConceptScore W2057685909C142724271 @default.
- W2057685909 hasConceptScore W2057685909C143998085 @default.
- W2057685909 hasConceptScore W2057685909C190283241 @default.
- W2057685909 hasConceptScore W2057685909C2777609662 @default.
- W2057685909 hasConceptScore W2057685909C2778227246 @default.
- W2057685909 hasConceptScore W2057685909C2778880634 @default.
- W2057685909 hasConceptScore W2057685909C2779083369 @default.
- W2057685909 hasConceptScore W2057685909C38180746 @default.
- W2057685909 hasConceptScore W2057685909C502942594 @default.
- W2057685909 hasConceptScore W2057685909C544855455 @default.
- W2057685909 hasConceptScore W2057685909C551621295 @default.
- W2057685909 hasConceptScore W2057685909C55493867 @default.
- W2057685909 hasConceptScore W2057685909C57742111 @default.
- W2057685909 hasConceptScore W2057685909C71924100 @default.