FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2057687079> ?p ?o ?g. }

• W2057687079 endingPage "3072" @default.
• W2057687079 startingPage "3068" @default.
• W2057687079 abstract "Growth of Listeria monocytogenes is mainly controlled by macrophages, which are activated by specific T cells. A potential role of CD8+ T cells by direct lysis of infected cells was investigated in perforin-deficient mice generated by homologous recombination. The absence of perforin-mediated cytotoxicity resulted in delayed clearance of Listeria from the spleen but not the liver after primary infection, overall susceptibility to Listeria however was not increased. Protection against a secondary infection was drastically impaired in perforin-deficient mice. Adoptive transfer of immune spleen cells to recipients revealed that anti-Listeria protection by CD8+ T cells from perforin-deficient versus normal mice was about 10-fold reduced in livers and about 100-fold reduced in the spleen of recipients. CD4+ T cells from immune control and perforin-deficient mice conferred comparable protection. These results indicate that the protective effect of CD8+ T cells against an intracellular bacterium mainly evident in secondary infection is mediated by a perforin-dependent pathway, presumably cytotoxicity, and less by other direct or indirect effector mechanisms." @default.
• W2057687079 created "2016-06-24" @default.
• W2057687079 creator A5009783885 @default.
• W2057687079 creator A5020252813 @default.
• W2057687079 creator A5031612228 @default.
• W2057687079 creator A5057774003 @default.
• W2057687079 creator A5071908815 @default.
• W2057687079 date "1994-12-01" @default.
• W2057687079 modified "2023-09-23" @default.
• W2057687079 title "CD8+ T cell-mediated protection against an intracellular bacterium by perforin-dependent cytotoxicity" @default.
• W2057687079 cites W1608588118 @default.
• W2057687079 cites W1850835571 @default.
• W2057687079 cites W1896151669 @default.
• W2057687079 cites W1987194359 @default.
• W2057687079 cites W1987854164 @default.
• W2057687079 cites W1990568245 @default.
• W2057687079 cites W2003080472 @default.
• W2057687079 cites W2009550948 @default.
• W2057687079 cites W2009576405 @default.
• W2057687079 cites W2009717034 @default.
• W2057687079 cites W2014916785 @default.
• W2057687079 cites W2018233688 @default.
• W2057687079 cites W2020500832 @default.
• W2057687079 cites W2022308523 @default.
• W2057687079 cites W2032626982 @default.
• W2057687079 cites W2056924500 @default.
• W2057687079 cites W2064706357 @default.
• W2057687079 cites W2068871282 @default.
• W2057687079 cites W2069695578 @default.
• W2057687079 cites W2085597255 @default.
• W2057687079 cites W2090439142 @default.
• W2057687079 cites W2118438470 @default.
• W2057687079 cites W2160217307 @default.
• W2057687079 doi "https://doi.org/10.1002/eji.1830241223" @default.
• W2057687079 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7805735" @default.
• W2057687079 hasPublicationYear "1994" @default.
• W2057687079 type Work @default.
• W2057687079 sameAs 2057687079 @default.
• W2057687079 citedByCount "225" @default.
• W2057687079 countsByYear W20576870792012 @default.
• W2057687079 countsByYear W20576870792013 @default.
• W2057687079 countsByYear W20576870792014 @default.
• W2057687079 countsByYear W20576870792015 @default.
• W2057687079 countsByYear W20576870792017 @default.
• W2057687079 countsByYear W20576870792018 @default.
• W2057687079 countsByYear W20576870792019 @default.
• W2057687079 countsByYear W20576870792020 @default.
• W2057687079 countsByYear W20576870792021 @default.
• W2057687079 countsByYear W20576870792022 @default.
• W2057687079 countsByYear W20576870792023 @default.
• W2057687079 crossrefType "journal-article" @default.
• W2057687079 hasAuthorship W2057687079A5009783885 @default.
• W2057687079 hasAuthorship W2057687079A5020252813 @default.
• W2057687079 hasAuthorship W2057687079A5031612228 @default.
• W2057687079 hasAuthorship W2057687079A5057774003 @default.
• W2057687079 hasAuthorship W2057687079A5071908815 @default.
• W2057687079 hasConcept C109316439 @default.
• W2057687079 hasConcept C153726182 @default.
• W2057687079 hasConcept C154317977 @default.
• W2057687079 hasConcept C167672396 @default.
• W2057687079 hasConcept C202751555 @default.
• W2057687079 hasConcept C203014093 @default.
• W2057687079 hasConcept C2776062744 @default.
• W2057687079 hasConcept C2776090121 @default.
• W2057687079 hasConcept C2780931953 @default.
• W2057687079 hasConcept C2781350384 @default.
• W2057687079 hasConcept C51785407 @default.
• W2057687079 hasConcept C523546767 @default.
• W2057687079 hasConcept C54355233 @default.
• W2057687079 hasConcept C55493867 @default.
• W2057687079 hasConcept C79879829 @default.
• W2057687079 hasConcept C86803240 @default.
• W2057687079 hasConcept C8891405 @default.
• W2057687079 hasConcept C89423630 @default.
• W2057687079 hasConcept C90375314 @default.
• W2057687079 hasConcept C95444343 @default.
• W2057687079 hasConceptScore W2057687079C109316439 @default.
• W2057687079 hasConceptScore W2057687079C153726182 @default.
• W2057687079 hasConceptScore W2057687079C154317977 @default.
• W2057687079 hasConceptScore W2057687079C167672396 @default.
• W2057687079 hasConceptScore W2057687079C202751555 @default.
• W2057687079 hasConceptScore W2057687079C203014093 @default.
• W2057687079 hasConceptScore W2057687079C2776062744 @default.
• W2057687079 hasConceptScore W2057687079C2776090121 @default.
• W2057687079 hasConceptScore W2057687079C2780931953 @default.
• W2057687079 hasConceptScore W2057687079C2781350384 @default.
• W2057687079 hasConceptScore W2057687079C51785407 @default.
• W2057687079 hasConceptScore W2057687079C523546767 @default.
• W2057687079 hasConceptScore W2057687079C54355233 @default.
• W2057687079 hasConceptScore W2057687079C55493867 @default.
• W2057687079 hasConceptScore W2057687079C79879829 @default.
• W2057687079 hasConceptScore W2057687079C86803240 @default.
• W2057687079 hasConceptScore W2057687079C8891405 @default.
• W2057687079 hasConceptScore W2057687079C89423630 @default.
• W2057687079 hasConceptScore W2057687079C90375314 @default.
• W2057687079 hasConceptScore W2057687079C95444343 @default.
• W2057687079 hasIssue "12" @default.
• W2057687079 hasLocation W20576870791 @default.

• next