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• W2057687911 startingPage "95" @default.
• W2057687911 abstract "Renal kallikrein is one of the tissue kallikreins, and the distal nephron is fully equipped as an element of the kallikrein-kinin system. Although a low excretion of urinary kallikrein has been reported in essential hypertension, the results from studies on patients with hypertension are not consistent. Congenitally hypertensive animals also excrete lowered levels of urinary kallikrein, but the effects of this are yet unknown. Extensive genetic and environmental studies on large Utah pedigrees suggest that the causes of hypertension are closely related to the combination of low kallikrein excretion and the potassium intake. Mutant kininogen-deficient Brown Norway-Katholiek rats, which cannot generate kinin in the urine, are very sensitive to salt loading and to sodium retention by aldosterone released by a non-pressor dose of angiotensin II, which results in hypertension. The major function of renal kallikrein-kinin system is to excrete sodium and water when excess sodium is present in the body. Failure of this function causes accumulation of sodium in the cerebrospinal fluid and erythrocytes, and probably in the vascular smooth muscle, which become sensitive to vasoconstrictors. We hypothesize that impaired function of the renal kallikrein-kinin system may play a pivotal role in the early development of hypertension. Inhibitors of kinin degradation in renal tubules and agents, which accelerate the secretion of urinary kallikrein from the connecting tubules and increase the generation of urinary kinin, may be novel drugs against hypertension." @default.
• W2057687911 created "2016-06-24" @default.
• W2057687911 creator A5001289757 @default.
• W2057687911 creator A5086946546 @default.
• W2057687911 date "1996-01-01" @default.
• W2057687911 modified "2023-10-18" @default.
• W2057687911 title "Pivotal Role of Renal Kallikrein-Kinin System in the Development of Hypertension and Approaches to New Drugs Based on This Relationship" @default.
• W2057687911 cites W101975661 @default.
• W2057687911 cites W1513280988 @default.
• W2057687911 cites W1534435876 @default.
• W2057687911 cites W1538283473 @default.
• W2057687911 cites W1545907965 @default.
• W2057687911 cites W1558653051 @default.
• W2057687911 cites W1596751461 @default.
• W2057687911 cites W1768094232 @default.
• W2057687911 cites W1818048824 @default.
• W2057687911 cites W1901938119 @default.
• W2057687911 cites W1907959623 @default.
• W2057687911 cites W1942335925 @default.
• W2057687911 cites W1962220685 @default.
• W2057687911 cites W1964255419 @default.
• W2057687911 cites W1964315955 @default.
• W2057687911 cites W1964416765 @default.
• W2057687911 cites W1965077308 @default.
• W2057687911 cites W1965131019 @default.
• W2057687911 cites W1965952910 @default.
• W2057687911 cites W1966102491 @default.
• W2057687911 cites W1966110783 @default.
• W2057687911 cites W1966249072 @default.
• W2057687911 cites W1966406818 @default.
• W2057687911 cites W1966453404 @default.
• W2057687911 cites W1968402169 @default.
• W2057687911 cites W1968721777 @default.
• W2057687911 cites W1969096323 @default.
• W2057687911 cites W1971910533 @default.
• W2057687911 cites W1972766768 @default.
• W2057687911 cites W1975204364 @default.
• W2057687911 cites W1975861373 @default.
• W2057687911 cites W1976887287 @default.
• W2057687911 cites W1977311294 @default.
• W2057687911 cites W1978574452 @default.
• W2057687911 cites W1981372032 @default.
• W2057687911 cites W1981841725 @default.
• W2057687911 cites W1985346221 @default.
• W2057687911 cites W1987329604 @default.
• W2057687911 cites W1989277075 @default.
• W2057687911 cites W1990481965 @default.
• W2057687911 cites W1993487455 @default.
• W2057687911 cites W1993671038 @default.
• W2057687911 cites W1994808188 @default.
• W2057687911 cites W1995640200 @default.
• W2057687911 cites W1997762637 @default.
• W2057687911 cites W1997844820 @default.
• W2057687911 cites W1998014245 @default.
• W2057687911 cites W2001957532 @default.
• W2057687911 cites W2002294257 @default.
• W2057687911 cites W2003625263 @default.
• W2057687911 cites W2004714575 @default.
• W2057687911 cites W2005680243 @default.
• W2057687911 cites W2009085222 @default.
• W2057687911 cites W2009990072 @default.
• W2057687911 cites W2010255151 @default.
• W2057687911 cites W2011699421 @default.
• W2057687911 cites W2012040369 @default.
• W2057687911 cites W2017107588 @default.
• W2057687911 cites W2020214606 @default.
• W2057687911 cites W2021490640 @default.
• W2057687911 cites W2021685721 @default.
• W2057687911 cites W2022612342 @default.
• W2057687911 cites W2023079411 @default.
• W2057687911 cites W2024311570 @default.
• W2057687911 cites W2024667090 @default.
• W2057687911 cites W2025003289 @default.
• W2057687911 cites W2025540579 @default.
• W2057687911 cites W2025562266 @default.
• W2057687911 cites W2027847802 @default.
• W2057687911 cites W2029678430 @default.
• W2057687911 cites W2031325309 @default.
• W2057687911 cites W2032467719 @default.
• W2057687911 cites W2033361525 @default.
• W2057687911 cites W2034191166 @default.
• W2057687911 cites W2036827114 @default.
• W2057687911 cites W2037314635 @default.
• W2057687911 cites W2038853037 @default.
• W2057687911 cites W2039571338 @default.
• W2057687911 cites W2040562793 @default.
• W2057687911 cites W2046200797 @default.
• W2057687911 cites W2047924579 @default.
• W2057687911 cites W2048393681 @default.
• W2057687911 cites W2048464838 @default.
• W2057687911 cites W2049111510 @default.
• W2057687911 cites W2049188017 @default.
• W2057687911 cites W2050532655 @default.
• W2057687911 cites W2050662311 @default.
• W2057687911 cites W2050959950 @default.
• W2057687911 cites W2051229276 @default.
• W2057687911 cites W2052412240 @default.
• W2057687911 cites W2052955033 @default.

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