FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2057688653> ?p ?o ?g. }

• W2057688653 endingPage "768" @default.
• W2057688653 startingPage "756" @default.
• W2057688653 abstract "A detailed 220-MHz NMR study has been made of the conformational properties for the homodinucleotide adenylyl-3' leads to 5'-adenosine, ApA, in D2O. Unambiguous signal assignments of all proton signals were made with the aid of selectively deuterated nucleotidyl units, ApA, ApA, and D-8ApA, and complete, accurate sets of NMR parameters were derived by simulation-iteration methods. Sets of limiting chemical shifts and coupling values were also obtained for ApA and constituent monomers 3'-AMP and 5'-AMP at infinite dilution and at identical ionization states for assessment of dimerization effects. Conformational properties were evaluated quantitatively for most of the conformational bonds of ApA and these are consistent with two compact folded dynamically averaged structures, a base-stacked right helical structure, I, characterized as anti, C3'-endo, g-, w,w' (320,330 degrees), g'g', gg, C3'-endo, anti, and a more loosely base-stacked loop structure, II, with anti, C3'-endo, g-, w,w' (80 degrees, 50 degrees), g'g', gg, C3'-endo, anti orientations. Dimerization produces a number of nucleotidyl conformational changes including a shift in ribose equilibrium C2'-endo (S) in equilibrium C3'-endo (N) in favor of C3'-endo in both Ap- and -pA (60:40 vs. 35:65 in monomers), a change in glycosidic torsion angle chiCN toward 0 degrees, and a greater locking-in of rotamers along bonds involved in the phosphodiester backbone. Moreover, there is clear evidence that the transitions from S leads to N forms and chiCN leads to 0 degrees are directly related to base stacking in ApA. Finally, ApA exists in solution as an equilibrium between I, II and an unstacked form(s) with as yet undetermined conformational features. Since C4'-C5', C5'-O5', and C3'-O3' bonds possess exceptional conformational stabilities, it is proposed that destacking occurs primarily by rotation about P-O5' and/or O3'-P. Predominant factors influencing the overall ApA conformation are thus base-base interaction and flexibility about P-O5' and O3'-P, with change of ribose conformation occurring in consequence of an alteration of chiCN, the latter in turn being governed by the need for maximum eta overlap of stacked adenine rings." @default.
• W2057688653 created "2016-06-24" @default.
• W2057688653 creator A5017447225 @default.
• W2057688653 creator A5089581728 @default.
• W2057688653 date "1976-02-24" @default.
• W2057688653 modified "2023-09-24" @default.
• W2057688653 title "NMR studies of nucleic acids in solution. III. Conformational properties of adenylyl-3' →.5'-adenosine in aqueous solution" @default.
• W2057688653 cites W1514701340 @default.
• W2057688653 cites W1534756035 @default.
• W2057688653 cites W1967297811 @default.
• W2057688653 cites W1969040166 @default.
• W2057688653 cites W1982350866 @default.
• W2057688653 cites W1990227667 @default.
• W2057688653 cites W1993008824 @default.
• W2057688653 cites W1993399961 @default.
• W2057688653 cites W1997721395 @default.
• W2057688653 cites W2003561875 @default.
• W2057688653 cites W2004053369 @default.
• W2057688653 cites W2004299505 @default.
• W2057688653 cites W2005727931 @default.
• W2057688653 cites W2022049288 @default.
• W2057688653 cites W2024805770 @default.
• W2057688653 cites W2030643546 @default.
• W2057688653 cites W2037118705 @default.
• W2057688653 cites W2039845189 @default.
• W2057688653 cites W2040188084 @default.
• W2057688653 cites W2050311252 @default.
• W2057688653 cites W2052715369 @default.
• W2057688653 cites W2052888487 @default.
• W2057688653 cites W2055089945 @default.
• W2057688653 cites W2060365534 @default.
• W2057688653 cites W2061822610 @default.
• W2057688653 cites W2063682137 @default.
• W2057688653 cites W2068958994 @default.
• W2057688653 cites W2069794250 @default.
• W2057688653 cites W2073134966 @default.
• W2057688653 cites W2080825199 @default.
• W2057688653 cites W2083262778 @default.
• W2057688653 cites W2091316326 @default.
• W2057688653 cites W2093513164 @default.
• W2057688653 cites W2093640723 @default.
• W2057688653 cites W2134258120 @default.
• W2057688653 cites W2147356897 @default.
• W2057688653 cites W2168704144 @default.
• W2057688653 cites W2169922455 @default.
• W2057688653 cites W2170680119 @default.
• W2057688653 cites W2312345887 @default.
• W2057688653 cites W2319524980 @default.
• W2057688653 cites W2325335868 @default.
• W2057688653 doi "https://doi.org/10.1021/bi00649a006" @default.
• W2057688653 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1247532" @default.
• W2057688653 hasPublicationYear "1976" @default.
• W2057688653 type Work @default.
• W2057688653 sameAs 2057688653 @default.
• W2057688653 citedByCount "72" @default.
• W2057688653 countsByYear W20576886532016 @default.
• W2057688653 countsByYear W20576886532017 @default.
• W2057688653 countsByYear W20576886532022 @default.
• W2057688653 crossrefType "journal-article" @default.
• W2057688653 hasAuthorship W2057688653A5017447225 @default.
• W2057688653 hasAuthorship W2057688653A5089581728 @default.
• W2057688653 hasConcept C104317684 @default.
• W2057688653 hasConcept C150487720 @default.
• W2057688653 hasConcept C166940927 @default.
• W2057688653 hasConcept C178790620 @default.
• W2057688653 hasConcept C181199279 @default.
• W2057688653 hasConcept C185592680 @default.
• W2057688653 hasConcept C18705241 @default.
• W2057688653 hasConcept C2777339483 @default.
• W2057688653 hasConcept C32909587 @default.
• W2057688653 hasConcept C38441620 @default.
• W2057688653 hasConcept C521977710 @default.
• W2057688653 hasConcept C55493867 @default.
• W2057688653 hasConcept C66974803 @default.
• W2057688653 hasConcept C67705224 @default.
• W2057688653 hasConcept C71240020 @default.
• W2057688653 hasConcept C8010536 @default.
• W2057688653 hasConceptScore W2057688653C104317684 @default.
• W2057688653 hasConceptScore W2057688653C150487720 @default.
• W2057688653 hasConceptScore W2057688653C166940927 @default.
• W2057688653 hasConceptScore W2057688653C178790620 @default.
• W2057688653 hasConceptScore W2057688653C181199279 @default.
• W2057688653 hasConceptScore W2057688653C185592680 @default.
• W2057688653 hasConceptScore W2057688653C18705241 @default.
• W2057688653 hasConceptScore W2057688653C2777339483 @default.
• W2057688653 hasConceptScore W2057688653C32909587 @default.
• W2057688653 hasConceptScore W2057688653C38441620 @default.
• W2057688653 hasConceptScore W2057688653C521977710 @default.
• W2057688653 hasConceptScore W2057688653C55493867 @default.
• W2057688653 hasConceptScore W2057688653C66974803 @default.
• W2057688653 hasConceptScore W2057688653C67705224 @default.
• W2057688653 hasConceptScore W2057688653C71240020 @default.
• W2057688653 hasConceptScore W2057688653C8010536 @default.
• W2057688653 hasIssue "4" @default.
• W2057688653 hasLocation W20576886531 @default.
• W2057688653 hasLocation W20576886532 @default.
• W2057688653 hasOpenAccess W2057688653 @default.
• W2057688653 hasPrimaryLocation W20576886531 @default.

• next