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• W2057694255 abstract "Summary Background When treating patients with severe ulcerative colitis ( UC ), accurate prediction of drug efficacy contributes to early clinical decision‐making. Aim To identify predictive factors and to develop a reliable prediction formula and a decision tree of response to intravenous ciclosporin treatment for severe UC . Methods Patients included in this study were those diagnosed with refractory severe UC who had undergone ciclosporin treatment between D ecember 2004 and M arch 2011 at a tertiary referral centre in J apan. Demographic and clinical parameters from all patients were analysed by multivariate statistics. Results Fifty‐two patients were included in this study (36.5% men with an average age of ciclosporin initiation of 40.2 ± 15.6 years). Thirty‐four patients (65.4%) were responders to the treatment with ciclosporin and avoided colectomy, 18 patients (34.6%) were nonresponders and underwent colectomy. Stepwise multiple logistic regression analysis identified four independent predictive factors of response to intravenous ciclosporin: age at hospitalisation ( AGE ), platelet count (×10 4 /μL) on the first day ( PLA ), Lichtiger score on the third day ( LIC ) and total protein (g/dL) on the third day minus total protein on the first day (Δ TP ). The calculation formula (8.5 − 0.16 × AGE + 0.21 × PLA − 0.61 × LIC + 2.3 × ΔTP < 0) predicted colectomy with an accuracy of 88.5% and the decision tree predicted colectomy with an accuracy of 90.4%. Conclusion The novel calculation formula and the decision tree effectively predict the clinical outcome of ciclosporin treatment for severe ulcerative colitis as early as on day 3 after starting ciclosporin treatment." @default.
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• W2057694255 date "2012-09-07" @default.
• W2057694255 modified "2023-10-02" @default.
• W2057694255 title "Predictive factors of response to intravenous ciclosporin in severe ulcerative colitis: the development of a novel prediction formula" @default.
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• W2057694255 doi "https://doi.org/10.1111/apt.12033" @default.
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