Matches in SemOpenAlex for { <https://semopenalex.org/work/W2057700337> ?p ?o ?g. }
- W2057700337 endingPage "247" @default.
- W2057700337 startingPage "238" @default.
- W2057700337 abstract "Cell replacement therapies that rely on in vitro differentiation of human neural progenitor cells are a promising strategy to compensate the progressive cell loss in neurodegenerative disorders like Parkinson’s disease. We and others observed, that the functional differentiation of progenitors in standard differentiation medium remains limited. The aim of the present study was to optimize neuronal in vitro differentiation by mimicking the physiological shift from depolarizing to hyperpolarizing conditions that occurs during early brain development. Differentiation was initiated using a depolarizing high potassium- and low sodium-containing medium. Subsequently, the high potassium-containing medium was replaced by a hyperpolarizing medium containing low potassium and high sodium concentrations. This two-phase strategy significantly promoted the expression of neuronal markers, enhanced neurite growth, enlarged sodium inward currents, and increased action potential firing. Thus, depolarizing followed by hyperpolarizing culture conditions enable developing human neural progenitor cells to adopt more mature functional qualities." @default.
- W2057700337 created "2016-06-24" @default.
- W2057700337 creator A5010114423 @default.
- W2057700337 creator A5019697934 @default.
- W2057700337 creator A5040045975 @default.
- W2057700337 creator A5041082258 @default.
- W2057700337 creator A5058620157 @default.
- W2057700337 creator A5063995923 @default.
- W2057700337 creator A5064139088 @default.
- W2057700337 date "2009-04-01" @default.
- W2057700337 modified "2023-09-27" @default.
- W2057700337 title "A new culturing strategy improves functional neuronal development of human neural progenitor cells" @default.
- W2057700337 cites W1500699899 @default.
- W2057700337 cites W1508623490 @default.
- W2057700337 cites W1534089166 @default.
- W2057700337 cites W1552650364 @default.
- W2057700337 cites W1563576581 @default.
- W2057700337 cites W1588629441 @default.
- W2057700337 cites W1705218924 @default.
- W2057700337 cites W1850595514 @default.
- W2057700337 cites W1963817491 @default.
- W2057700337 cites W1967440885 @default.
- W2057700337 cites W1968151094 @default.
- W2057700337 cites W1970828908 @default.
- W2057700337 cites W1972578909 @default.
- W2057700337 cites W1983274440 @default.
- W2057700337 cites W1988945207 @default.
- W2057700337 cites W1989004805 @default.
- W2057700337 cites W1994974272 @default.
- W2057700337 cites W1995760568 @default.
- W2057700337 cites W2004419170 @default.
- W2057700337 cites W2006376420 @default.
- W2057700337 cites W2006655453 @default.
- W2057700337 cites W2016439164 @default.
- W2057700337 cites W2016961314 @default.
- W2057700337 cites W2029853228 @default.
- W2057700337 cites W2032763091 @default.
- W2057700337 cites W2035831169 @default.
- W2057700337 cites W2037968226 @default.
- W2057700337 cites W2046964936 @default.
- W2057700337 cites W2052499370 @default.
- W2057700337 cites W2054072710 @default.
- W2057700337 cites W2059524152 @default.
- W2057700337 cites W2064363302 @default.
- W2057700337 cites W2064960897 @default.
- W2057700337 cites W2069226218 @default.
- W2057700337 cites W2070833074 @default.
- W2057700337 cites W2091653674 @default.
- W2057700337 cites W2092438308 @default.
- W2057700337 cites W2096436305 @default.
- W2057700337 cites W2101556559 @default.
- W2057700337 cites W2102329408 @default.
- W2057700337 cites W2106452927 @default.
- W2057700337 cites W2108209263 @default.
- W2057700337 cites W2113210947 @default.
- W2057700337 cites W2117058176 @default.
- W2057700337 cites W2117523148 @default.
- W2057700337 cites W2121009504 @default.
- W2057700337 cites W2129358058 @default.
- W2057700337 cites W2137591095 @default.
- W2057700337 cites W2141260882 @default.
- W2057700337 doi "https://doi.org/10.1111/j.1471-4159.2009.05954.x" @default.
- W2057700337 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19187439" @default.
- W2057700337 hasPublicationYear "2009" @default.
- W2057700337 type Work @default.
- W2057700337 sameAs 2057700337 @default.
- W2057700337 citedByCount "24" @default.
- W2057700337 countsByYear W20577003372012 @default.
- W2057700337 countsByYear W20577003372013 @default.
- W2057700337 countsByYear W20577003372014 @default.
- W2057700337 countsByYear W20577003372015 @default.
- W2057700337 countsByYear W20577003372016 @default.
- W2057700337 countsByYear W20577003372018 @default.
- W2057700337 countsByYear W20577003372019 @default.
- W2057700337 countsByYear W20577003372020 @default.
- W2057700337 countsByYear W20577003372021 @default.
- W2057700337 crossrefType "journal-article" @default.
- W2057700337 hasAuthorship W2057700337A5010114423 @default.
- W2057700337 hasAuthorship W2057700337A5019697934 @default.
- W2057700337 hasAuthorship W2057700337A5040045975 @default.
- W2057700337 hasAuthorship W2057700337A5041082258 @default.
- W2057700337 hasAuthorship W2057700337A5058620157 @default.
- W2057700337 hasAuthorship W2057700337A5063995923 @default.
- W2057700337 hasAuthorship W2057700337A5064139088 @default.
- W2057700337 hasBestOaLocation W20577003371 @default.
- W2057700337 hasConcept C104317684 @default.
- W2057700337 hasConcept C113246987 @default.
- W2057700337 hasConcept C12554922 @default.
- W2057700337 hasConcept C136834591 @default.
- W2057700337 hasConcept C148738053 @default.
- W2057700337 hasConcept C15729860 @default.
- W2057700337 hasConcept C169760540 @default.
- W2057700337 hasConcept C185592680 @default.
- W2057700337 hasConcept C201750760 @default.
- W2057700337 hasConcept C202751555 @default.
- W2057700337 hasConcept C2778794669 @default.
- W2057700337 hasConcept C28328180 @default.
- W2057700337 hasConcept C4141045 @default.