Matches in SemOpenAlex for { <https://semopenalex.org/work/W2057701454> ?p ?o ?g. }
- W2057701454 endingPage "147" @default.
- W2057701454 startingPage "143" @default.
- W2057701454 abstract "Squamous cell carcinoma antigen 1 (SCCA1), which belongs to serine proteinase inhibitor (serpin) superfamily, inhibits papain-like cysteine proteinase. Recently, it has been reported that SCCA1 acts not only as a proteinase inhibitor but also as an inhibitor of UV-induced apoptosis via suppression of the activity of c-Jun NH2-terminal kinase (JNK1). The present study determined the crystal structure of SCCA1, suggesting that the reactive center loop (RCL) of SCCA1, a recognition site of proteinase, is very flexible and located away form the main-body of SCCA1. We show that the inhibitory effect of SCCA1 on the kinase activity of JNK1 is lost when the RCL was truncated. Furthermore, we found that a mutant protein created by replacing one amino acid in RCL maintain the suppressive activity to JNK1, whereas the inhibitory effect to proteinase is obviously decreased." @default.
- W2057701454 created "2016-06-24" @default.
- W2057701454 creator A5012124756 @default.
- W2057701454 creator A5026668762 @default.
- W2057701454 creator A5058422644 @default.
- W2057701454 creator A5059328773 @default.
- W2057701454 creator A5062808952 @default.
- W2057701454 creator A5083330062 @default.
- W2057701454 date "2009-02-01" @default.
- W2057701454 modified "2023-10-16" @default.
- W2057701454 title "Crystal structure of SCCA1 and insight about the interaction with JNK1" @default.
- W2057701454 cites W1539796472 @default.
- W2057701454 cites W1966562580 @default.
- W2057701454 cites W1968321321 @default.
- W2057701454 cites W1969162232 @default.
- W2057701454 cites W1970839214 @default.
- W2057701454 cites W1983164381 @default.
- W2057701454 cites W1983562760 @default.
- W2057701454 cites W1990808614 @default.
- W2057701454 cites W1991858888 @default.
- W2057701454 cites W1995017064 @default.
- W2057701454 cites W1996607909 @default.
- W2057701454 cites W2001641653 @default.
- W2057701454 cites W2008161233 @default.
- W2057701454 cites W2015207544 @default.
- W2057701454 cites W2017708875 @default.
- W2057701454 cites W2032615313 @default.
- W2057701454 cites W2042953815 @default.
- W2057701454 cites W2045959349 @default.
- W2057701454 cites W2047815393 @default.
- W2057701454 cites W2056993860 @default.
- W2057701454 cites W2065546035 @default.
- W2057701454 cites W2067896166 @default.
- W2057701454 cites W2069263559 @default.
- W2057701454 cites W2074146726 @default.
- W2057701454 cites W2088744910 @default.
- W2057701454 cites W2103659092 @default.
- W2057701454 cites W2118587530 @default.
- W2057701454 cites W2125983644 @default.
- W2057701454 cites W2163021423 @default.
- W2057701454 cites W2170327826 @default.
- W2057701454 cites W2171215167 @default.
- W2057701454 doi "https://doi.org/10.1016/j.bbrc.2009.01.057" @default.
- W2057701454 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19166818" @default.
- W2057701454 hasPublicationYear "2009" @default.
- W2057701454 type Work @default.
- W2057701454 sameAs 2057701454 @default.
- W2057701454 citedByCount "22" @default.
- W2057701454 countsByYear W20577014542013 @default.
- W2057701454 countsByYear W20577014542014 @default.
- W2057701454 countsByYear W20577014542015 @default.
- W2057701454 countsByYear W20577014542016 @default.
- W2057701454 countsByYear W20577014542017 @default.
- W2057701454 countsByYear W20577014542019 @default.
- W2057701454 countsByYear W20577014542020 @default.
- W2057701454 countsByYear W20577014542021 @default.
- W2057701454 countsByYear W20577014542022 @default.
- W2057701454 countsByYear W20577014542023 @default.
- W2057701454 crossrefType "journal-article" @default.
- W2057701454 hasAuthorship W2057701454A5012124756 @default.
- W2057701454 hasAuthorship W2057701454A5026668762 @default.
- W2057701454 hasAuthorship W2057701454A5058422644 @default.
- W2057701454 hasAuthorship W2057701454A5059328773 @default.
- W2057701454 hasAuthorship W2057701454A5062808952 @default.
- W2057701454 hasAuthorship W2057701454A5083330062 @default.
- W2057701454 hasConcept C104317684 @default.
- W2057701454 hasConcept C153911025 @default.
- W2057701454 hasConcept C181199279 @default.
- W2057701454 hasConcept C182220744 @default.
- W2057701454 hasConcept C184235292 @default.
- W2057701454 hasConcept C185592680 @default.
- W2057701454 hasConcept C2776414213 @default.
- W2057701454 hasConcept C2776714187 @default.
- W2057701454 hasConcept C2777807008 @default.
- W2057701454 hasConcept C2778965386 @default.
- W2057701454 hasConcept C2779201268 @default.
- W2057701454 hasConcept C2779832904 @default.
- W2057701454 hasConcept C2909000736 @default.
- W2057701454 hasConcept C55493867 @default.
- W2057701454 hasConcept C86803240 @default.
- W2057701454 hasConceptScore W2057701454C104317684 @default.
- W2057701454 hasConceptScore W2057701454C153911025 @default.
- W2057701454 hasConceptScore W2057701454C181199279 @default.
- W2057701454 hasConceptScore W2057701454C182220744 @default.
- W2057701454 hasConceptScore W2057701454C184235292 @default.
- W2057701454 hasConceptScore W2057701454C185592680 @default.
- W2057701454 hasConceptScore W2057701454C2776414213 @default.
- W2057701454 hasConceptScore W2057701454C2776714187 @default.
- W2057701454 hasConceptScore W2057701454C2777807008 @default.
- W2057701454 hasConceptScore W2057701454C2778965386 @default.
- W2057701454 hasConceptScore W2057701454C2779201268 @default.
- W2057701454 hasConceptScore W2057701454C2779832904 @default.
- W2057701454 hasConceptScore W2057701454C2909000736 @default.
- W2057701454 hasConceptScore W2057701454C55493867 @default.
- W2057701454 hasConceptScore W2057701454C86803240 @default.
- W2057701454 hasIssue "1" @default.
- W2057701454 hasLocation W20577014541 @default.
- W2057701454 hasLocation W20577014542 @default.