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- W2057702458 abstract "<h2>Abstract</h2><h3>Background</h3> Current clinical guidelines recommend that risk stratification for ischaemic stroke in patients with nonvalvular AF (NVAF) should be performed using the CHA<sub>2</sub>DS<sub>2</sub>-VASc score (Congestive heart failure, Hypertension, Age≥75years [double], Diabetes mellitus, previous thromboembolism [double], Vascular disease, Age 65–74years, and female gender) to aid decision making for antithrombotic treatment, with a preference for Non-Vitamin K Oral Anticoagulants (NOACs) in those with CHA<sub>2</sub>DS<sub>2</sub>-VASc score ≥1. However, CHA<sub>2</sub>DS<sub>2</sub>-VASc score is not recommended in the 2014 Japanese Circulation Society (JCS) guidelines for patients with NVAF. <h3>Methods</h3> To assess the impact of the JCS approach to stroke prevention in AF, and model the impact of using a CHA<sub>2</sub>DS<sub>2</sub>-VASc based 2-step decision making strategy, we calculated the incidence of ischaemic stroke in NVAF patients without OAC on basis of the CHADS<sub>2</sub> and CHA<sub>2</sub>DS<sub>2</sub>-VASc scores using published Japanese data, and estimated the preventable number of stroke events. <h3>Results</h3> Using a CHA<sub>2</sub>DS<sub>2</sub>-VASc-based approach, the potential annual stroke events based on the estimated total number of NVAF patients in Japan was 889,000, as follows: 4369 for dabigatran 150mg, 6049 for dabigatran 110mg, 5918 for rivaroxaban (intention-to-treat; ITT), 5302 for apixaban, 5843 for edoxaban 60mg (ITT), and 7598 for edoxaban 30mg (ITT), respectively. Using a CHADS<sub>2</sub> score-based approach, the number of potential stroke events was much greater for each agent. <h3>Conclusion</h3> Our modelling analysis has shown that when considering antithrombotic treatment for Japanese NVAF patients, using a CHA<sub>2</sub>DS<sub>2</sub>-VASc-based approach would allow greater opportunities for stroke prevention." @default.
- W2057702458 created "2016-06-24" @default.
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- W2057702458 date "2015-02-01" @default.
- W2057702458 modified "2023-09-27" @default.
- W2057702458 title "Stroke risk reduction with oral anticoagulation using CHA2DS2-VASc in a Japanese AF population: A modeling analysis" @default.
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- W2057702458 doi "https://doi.org/10.1016/j.ijcard.2014.11.196" @default.
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