Matches in SemOpenAlex for { <https://semopenalex.org/work/W2057702943> ?p ?o ?g. }
Showing items 1 to 87 of
87
with 100 items per page.
- W2057702943 abstract "The transcription factor Odd-skipped related 2 (Osr2) functions in craniofacial and limb developments in mammals. We previously found that Osr2 gene expression is regulated by intracellular transcription factors such as Runx2, and C/EBP, whereas it remains unclear if extracellular factors would functionally regulate the Osr2 expression. In this study, we showed that TGF-β down-regulated the Osr2 expression, which is involved in regulation of cellular migration and cell cycle. Furthermore, the down-regulation was found to be mediated by Smad3/Smad4 and p38/ATF2 signaling molecules. The Osr2 promoter was shown to possess Smad3/4 binding element and ATF2 binding element between -647 and -64 of promoter. TGF-β induced cellular migration in C3H10T1/2 cells and arrested cell cycle at G1 phase in NMuMG-Fucci cells. In contrast, the Osr2 reduced the migration and also stimulated the cell-cycle progression. These results suggest that Osr2 is involved in TGF-β regulating cell migration and cell cycle via a Smad3-ATF2 transcriptional complex mediating pathway." @default.
- W2057702943 created "2016-06-24" @default.
- W2057702943 creator A5054926871 @default.
- W2057702943 creator A5056015870 @default.
- W2057702943 date "2012-05-01" @default.
- W2057702943 modified "2023-10-12" @default.
- W2057702943 title "Negative regulation of Odd-skipped related 2 by TGF-beta achieves the induction of cellular migration and the arrest of cell cycle" @default.
- W2057702943 cites W1560888790 @default.
- W2057702943 cites W1565561072 @default.
- W2057702943 cites W1598641583 @default.
- W2057702943 cites W1974801498 @default.
- W2057702943 cites W1975988802 @default.
- W2057702943 cites W1977657840 @default.
- W2057702943 cites W1983628734 @default.
- W2057702943 cites W1996435746 @default.
- W2057702943 cites W1996875432 @default.
- W2057702943 cites W1998403294 @default.
- W2057702943 cites W1998870114 @default.
- W2057702943 cites W2009487182 @default.
- W2057702943 cites W2009629707 @default.
- W2057702943 cites W2009760295 @default.
- W2057702943 cites W2026876559 @default.
- W2057702943 cites W2026932801 @default.
- W2057702943 cites W2034717801 @default.
- W2057702943 cites W2039872830 @default.
- W2057702943 cites W2051540590 @default.
- W2057702943 cites W2076025030 @default.
- W2057702943 cites W2090035694 @default.
- W2057702943 cites W2154568166 @default.
- W2057702943 cites W2158632638 @default.
- W2057702943 doi "https://doi.org/10.1016/j.bbrc.2012.04.064" @default.
- W2057702943 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22542937" @default.
- W2057702943 hasPublicationYear "2012" @default.
- W2057702943 type Work @default.
- W2057702943 sameAs 2057702943 @default.
- W2057702943 citedByCount "3" @default.
- W2057702943 countsByYear W20577029432014 @default.
- W2057702943 countsByYear W20577029432015 @default.
- W2057702943 countsByYear W20577029432022 @default.
- W2057702943 crossrefType "journal-article" @default.
- W2057702943 hasAuthorship W2057702943A5054926871 @default.
- W2057702943 hasAuthorship W2057702943A5056015870 @default.
- W2057702943 hasConcept C104317684 @default.
- W2057702943 hasConcept C137738243 @default.
- W2057702943 hasConcept C1491633281 @default.
- W2057702943 hasConcept C29537977 @default.
- W2057702943 hasConcept C54355233 @default.
- W2057702943 hasConcept C86339819 @default.
- W2057702943 hasConcept C86803240 @default.
- W2057702943 hasConcept C95444343 @default.
- W2057702943 hasConceptScore W2057702943C104317684 @default.
- W2057702943 hasConceptScore W2057702943C137738243 @default.
- W2057702943 hasConceptScore W2057702943C1491633281 @default.
- W2057702943 hasConceptScore W2057702943C29537977 @default.
- W2057702943 hasConceptScore W2057702943C54355233 @default.
- W2057702943 hasConceptScore W2057702943C86339819 @default.
- W2057702943 hasConceptScore W2057702943C86803240 @default.
- W2057702943 hasConceptScore W2057702943C95444343 @default.
- W2057702943 hasFunder F4320334764 @default.
- W2057702943 hasLocation W20577029431 @default.
- W2057702943 hasLocation W20577029432 @default.
- W2057702943 hasOpenAccess W2057702943 @default.
- W2057702943 hasPrimaryLocation W20577029431 @default.
- W2057702943 hasRelatedWork W1971846249 @default.
- W2057702943 hasRelatedWork W1984873332 @default.
- W2057702943 hasRelatedWork W1996448199 @default.
- W2057702943 hasRelatedWork W1999491381 @default.
- W2057702943 hasRelatedWork W2000139434 @default.
- W2057702943 hasRelatedWork W2009893232 @default.
- W2057702943 hasRelatedWork W2018459525 @default.
- W2057702943 hasRelatedWork W2037777120 @default.
- W2057702943 hasRelatedWork W2063764068 @default.
- W2057702943 hasRelatedWork W2079262823 @default.
- W2057702943 hasRelatedWork W2079743735 @default.
- W2057702943 hasRelatedWork W2084972992 @default.
- W2057702943 hasRelatedWork W2096171314 @default.
- W2057702943 hasRelatedWork W2111391000 @default.
- W2057702943 hasRelatedWork W2133309812 @default.
- W2057702943 hasRelatedWork W2144578935 @default.
- W2057702943 hasRelatedWork W2163647575 @default.
- W2057702943 hasRelatedWork W2694649194 @default.
- W2057702943 hasRelatedWork W2920851810 @default.
- W2057702943 hasRelatedWork W3025917918 @default.
- W2057702943 isParatext "false" @default.
- W2057702943 isRetracted "false" @default.
- W2057702943 magId "2057702943" @default.
- W2057702943 workType "article" @default.