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- W2057703595 abstract "Macromolecular contrast media (MMCM) specifically designed to enhance the blood pool do not substantially penetrate the endothelial barrier of most normal tissues but will penetrate tumor microvascular endothelium readily. Consequently, steady increase in tissue accumulation and resulting MRI enhancement, relative to the temporal response for blood enhancement, have been used to detect and estimate the tumor microvascular permeability. Quantitative estimates of tissue blood volume and estimates of the permeability may be used to differentiate the biology of tumors. MMCM-enhanced MRI techniques can be used to improve the specificity of tumor diagnosis and lesion differentiation (1,2). Quantitative information about the transendothelial diffusion of blood pool agents comes from both macroscopic and microscopic approaches. The transport can be monitored macroscopically by measuring the MR signal intensities (SI) in blood and tissues after contrast agent administration. Microscopic distribution of a blood pool agent in normal tissue has been studied using electron microscopy (3). We developed an MRI and light microscopically detectable blood pool agent comprised of human serum albumin (HSA) double-labeled with Gd-DTPA groups and biotin to permit correlation of the histologic transcapillary diffusion of MMCM as a function of time in normal and neoplastic tissues to the MR-derived estimates of capillary leakiness." @default.
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- W2057703595 date "2002-01-01" @default.
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- W2057703595 title "Comparison of MR Contrast–enhancing Properties of Albumin-(biotin)10-(gadopentetate)25, a Macromolecular MR Blood Pool Contrast Agent, and Its Microscopic Distribution" @default.
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- W2057703595 doi "https://doi.org/10.1016/s1076-6332(03)80451-8" @default.
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