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• W2057707751 abstract "In order to get more insight into the mechanism of asbestos-related lung cancer, the mutagenic potential of asbestos was examined in vivo in rat lung. Groups of five transgenic λ-lacI (Big Blue™) rats were intratracheally instilled with single doses of 1 or 2 mg, or with four weekly doses of 2 mg, per animal of the amosite asbestos. Sixteen weeks after instillation, the mutation frequency was found to be increased in lung DNA by 2-fold at doses of 2 mg (P = 0.035) and of 4 × 2 mg (P = 0.007) amosite. No significant changes were observed after 4 weeks of exposure. In separate experiments, wild-type F344 rats were treated by the same regimen as described above and markers of inflammation, genotoxicity, cell proliferation and lung tissue damage were analysed. Our results indicate a weak but persistent inflammation and cell proliferation which possibly plays a major role in the observed mutagenic effect." @default.
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• W2057707751 date "2004-09-01" @default.
• W2057707751 modified "2023-10-17" @default.
• W2057707751 title "Mutagenesis by asbestos in the lung of λ-lacI transgenic rats" @default.
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• W2057707751 doi "https://doi.org/10.1016/j.mrfmmm.2004.06.023" @default.
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