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- W2057714910 abstract "Wide interest has been aroused by a recent report that temporary remissions of acute leukemia have been produced in children with the aid of a so-called folic acid antagonist. Despite its toxicity, Farber, Diamond, Mercer, Sylvester and Wolff 1 have found that the administration of aminopterin® (4-aminopteroyl glutamic acid) produces, in the majority of patients treated, dramatic clinical improvement together with striking alteration toward normal of peripheral blood and bone marrow pictures. Comparable remissions of appreciable duration have never before been produced by numerous therapeutic agents. On the other hand, sporadically, remissions of acute leukemia have been observed to occur without apparent relationship to therapy. Authenticated instances of spontaneous remission now seem worthy of review because they constitute a control group which may be compared with examples of drug-induced remission. Ten such cases have been described since 1931, and an additional example of unusually long remission (twenty-one months) is herein" @default.
- W2057714910 created "2016-06-24" @default.
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- W2057714910 date "1949-06-18" @default.
- W2057714910 modified "2023-10-14" @default.
- W2057714910 title "SPONTANEOUS REMISSION IN ACUTE LEUKEMIA" @default.
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- W2057714910 doi "https://doi.org/10.1001/jama.1949.02900420009003" @default.
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