FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2057716967> ?p ?o ?g. }

• W2057716967 endingPage "264" @default.
• W2057716967 startingPage "254" @default.
• W2057716967 abstract "Cytokeratin A (no. 8) is a cytoskeletal protein (Mr, approximately 53,000 in bovine cells) which is typical of all simple epithelia, is widespread in all cultured epithelial cells, and together with its partner cytokeratin D, is the first cytokeratin expressed during embryogenesis (synonyms for this protein are Endo A and TROMA-1 antigen). We isolated a clone (pKB8(1] from a pUC8 cDNA library prepared from poly(A)+-RNA of bovine bladder urothelium which contains the 3' nontranslated portion and the sequence coding for the carboxyterminal tail and almost the whole of the alpha-helical rod (369 amino acids). Northern-blot analysis showed that the mRNA coding for this cytokeratin is specifically synthesized in various epithelial tissues and in epithelial cell culture lines. The amino acid sequence of this cytokeratin, when compared with the sequences of other intermediate filament (IF) proteins, exhibits a high and specific homology with other cytokeratins of the basic (type II) subfamily; this homology is, however, restricted to the rod portion. The tail region, which is rich in hydroxy-amino acids (approximately 35%), is unique among the type-II cytokeratins in that it does not exhibit subdivision in three domains, specifically lacking the glycine-rich middle domain. Sequence comparison with a partial sequence of the corresponding cytokeratin of the amphibian species, Xenopus laevis, indicated high evolutionary conservation. The high sequence homology of bovine cytokeratin A with published sequences of human tissue polypeptide antigen (TPA), a soluble serum component used as tumor marker in clinical oncology, supports the view that TPA is a proteolytically solubilized fragment containing the rod portion of human cytokeratin no. 8. Our analysis of clone pKB8(1) made possible the first comparison of a simple epithelial cytokeratin with epidermal keratins and other IF proteins. This showed that, in some important molecular features, cytokeratin A (no. 8) differs drastically from the epidermal members of the same cytokeratin subfamily, probably reflecting different cellular functions of the tail region in stratified and simple epithelia." @default.
• W2057716967 created "2016-06-24" @default.
• W2057716967 creator A5000001579 @default.
• W2057716967 creator A5037306910 @default.
• W2057716967 creator A5052267229 @default.
• W2057716967 date "1986-03-01" @default.
• W2057716967 modified "2023-10-14" @default.
• W2057716967 title "Cytokeratin expression in simple epithelia" @default.
• W2057716967 cites W129824029 @default.
• W2057716967 cites W133358735 @default.
• W2057716967 cites W1497884082 @default.
• W2057716967 cites W1530776845 @default.
• W2057716967 cites W1535662492 @default.
• W2057716967 cites W1558516755 @default.
• W2057716967 cites W1572412709 @default.
• W2057716967 cites W1583233593 @default.
• W2057716967 cites W1650344403 @default.
• W2057716967 cites W1871140207 @default.
• W2057716967 cites W188844709 @default.
• W2057716967 cites W1969779303 @default.
• W2057716967 cites W1972092014 @default.
• W2057716967 cites W1980755114 @default.
• W2057716967 cites W1988798314 @default.
• W2057716967 cites W1990204628 @default.
• W2057716967 cites W1991934190 @default.
• W2057716967 cites W1997469925 @default.
• W2057716967 cites W2003434690 @default.
• W2057716967 cites W2011770798 @default.
• W2057716967 cites W2012527668 @default.
• W2057716967 cites W2016693266 @default.
• W2057716967 cites W2017205195 @default.
• W2057716967 cites W2017359994 @default.
• W2057716967 cites W2020386377 @default.
• W2057716967 cites W2021816639 @default.
• W2057716967 cites W2024685401 @default.
• W2057716967 cites W2025655860 @default.
• W2057716967 cites W2025785510 @default.
• W2057716967 cites W2035776517 @default.
• W2057716967 cites W2042333171 @default.
• W2057716967 cites W2044061053 @default.
• W2057716967 cites W2044295198 @default.
• W2057716967 cites W2047331683 @default.
• W2057716967 cites W2050567744 @default.
• W2057716967 cites W2058835187 @default.
• W2057716967 cites W2060333964 @default.
• W2057716967 cites W2067259243 @default.
• W2057716967 cites W2067949392 @default.
• W2057716967 cites W2067975552 @default.
• W2057716967 cites W2069860300 @default.
• W2057716967 cites W2071761976 @default.
• W2057716967 cites W2079021200 @default.
• W2057716967 cites W2083361243 @default.
• W2057716967 cites W2087985795 @default.
• W2057716967 cites W2088925212 @default.
• W2057716967 cites W2089433310 @default.
• W2057716967 cites W2090162704 @default.
• W2057716967 cites W2091623476 @default.
• W2057716967 cites W2095450147 @default.
• W2057716967 cites W2126332265 @default.
• W2057716967 cites W2132417094 @default.
• W2057716967 cites W2133074709 @default.
• W2057716967 cites W2138270253 @default.
• W2057716967 cites W2148294261 @default.
• W2057716967 cites W2154810865 @default.
• W2057716967 cites W2161524167 @default.
• W2057716967 cites W216441896 @default.
• W2057716967 cites W2167051624 @default.
• W2057716967 cites W2169856028 @default.
• W2057716967 cites W2235731464 @default.
• W2057716967 cites W2314789569 @default.
• W2057716967 cites W251109853 @default.
• W2057716967 cites W3024152856 @default.
• W2057716967 cites W4327766605 @default.
• W2057716967 cites W817732688 @default.
• W2057716967 doi "https://doi.org/10.1111/j.1432-0436.1986.tb00788.x" @default.
• W2057716967 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2422084" @default.
• W2057716967 hasPublicationYear "1986" @default.
• W2057716967 type Work @default.
• W2057716967 sameAs 2057716967 @default.
• W2057716967 citedByCount "55" @default.
• W2057716967 countsByYear W20577169672013 @default.
• W2057716967 countsByYear W20577169672015 @default.
• W2057716967 crossrefType "journal-article" @default.
• W2057716967 hasAuthorship W2057716967A5000001579 @default.
• W2057716967 hasAuthorship W2057716967A5037306910 @default.
• W2057716967 hasAuthorship W2057716967A5052267229 @default.
• W2057716967 hasConcept C104317684 @default.
• W2057716967 hasConcept C105580179 @default.
• W2057716967 hasConcept C142669718 @default.
• W2057716967 hasConcept C1491633281 @default.
• W2057716967 hasConcept C153911025 @default.
• W2057716967 hasConcept C165525559 @default.
• W2057716967 hasConcept C167625842 @default.
• W2057716967 hasConcept C177707886 @default.
• W2057716967 hasConcept C187882448 @default.
• W2057716967 hasConcept C203014093 @default.
• W2057716967 hasConcept C204232928 @default.
• W2057716967 hasConcept C2779012181 @default.

• next