Matches in SemOpenAlex for { <https://semopenalex.org/work/W2057722433> ?p ?o ?g. }
- W2057722433 endingPage "54" @default.
- W2057722433 startingPage "43" @default.
- W2057722433 abstract "We are quantitatively evaluating the acquisition of neocortical neurons through key stages of development including neurogenesis, migration, and synaptogenesis. Here we expand upon a previous computational model describing neocortical neurogenesis in the rat and mouse [Dev. Neurosci. 24 (2002) 467], to include the period of synaptogenesis (P0-P14) when programmed cell death (PCD) is known to play a major role in shaping the neocortex. We also quantitatively evaluate differing hypotheses on the role of cell death during neurogenesis. This new model construct allows prediction of acquisition of adult neuronal number in the rat and mouse neocortex from the beginning of neurogenesis through synaptogenesis. The mathematical model output is validated by independently derived stereologically determined neuron number estimates in the adult rat and mouse. Simulations suggest cell death during synaptogenesis reduces the neocortical neuronal population by 20-30%, while cell death of progenitor cells and newly formed neurons during neurogenesis may reduce output by as much as 24%. However, higher death rates during neurogenesis as suggested by some research would deplete the progenitor population, not allowing for the vast expansion that is the hallmark of the mammalian neocortex. Furthermore, our simulations suggest the clearance time of dying neurons labeled by TUNEL or pyknosis is relatively short, between 1 and 4 h, corroborating experimental research. This novel mathematical model for adult neocortical neuronal acquisition allows for in silico analysis of normal and perturbed states of neocortical development as well as interspecies and evolutionary analyses of neocortical development." @default.
- W2057722433 created "2016-06-24" @default.
- W2057722433 creator A5001722260 @default.
- W2057722433 creator A5079577082 @default.
- W2057722433 creator A5090667749 @default.
- W2057722433 date "2004-07-01" @default.
- W2057722433 modified "2023-10-16" @default.
- W2057722433 title "The role of cell death during neocortical neurogenesis and synaptogenesis: implications from a computational model for the rat and mouse" @default.
- W2057722433 cites W1506357334 @default.
- W2057722433 cites W1513029763 @default.
- W2057722433 cites W1542280544 @default.
- W2057722433 cites W1559406855 @default.
- W2057722433 cites W1560129441 @default.
- W2057722433 cites W1572812739 @default.
- W2057722433 cites W1582081614 @default.
- W2057722433 cites W1623155147 @default.
- W2057722433 cites W1638014378 @default.
- W2057722433 cites W1671067214 @default.
- W2057722433 cites W175783626 @default.
- W2057722433 cites W1869240171 @default.
- W2057722433 cites W1884108341 @default.
- W2057722433 cites W1918909705 @default.
- W2057722433 cites W1919729993 @default.
- W2057722433 cites W1966492450 @default.
- W2057722433 cites W1968776273 @default.
- W2057722433 cites W1973357067 @default.
- W2057722433 cites W1975003415 @default.
- W2057722433 cites W1975024858 @default.
- W2057722433 cites W1975258180 @default.
- W2057722433 cites W1975466959 @default.
- W2057722433 cites W1981276731 @default.
- W2057722433 cites W1982784171 @default.
- W2057722433 cites W1982816030 @default.
- W2057722433 cites W1987785848 @default.
- W2057722433 cites W1993902481 @default.
- W2057722433 cites W1995953333 @default.
- W2057722433 cites W1997406173 @default.
- W2057722433 cites W1998121788 @default.
- W2057722433 cites W2000352412 @default.
- W2057722433 cites W2003152729 @default.
- W2057722433 cites W2017662277 @default.
- W2057722433 cites W2019260069 @default.
- W2057722433 cites W2025670633 @default.
- W2057722433 cites W2025968815 @default.
- W2057722433 cites W2028742810 @default.
- W2057722433 cites W2033160816 @default.
- W2057722433 cites W2041042514 @default.
- W2057722433 cites W2042279121 @default.
- W2057722433 cites W2047986852 @default.
- W2057722433 cites W2054875089 @default.
- W2057722433 cites W2060982272 @default.
- W2057722433 cites W2067342005 @default.
- W2057722433 cites W2073754785 @default.
- W2057722433 cites W2080570820 @default.
- W2057722433 cites W2081560586 @default.
- W2057722433 cites W2083192044 @default.
- W2057722433 cites W2083778068 @default.
- W2057722433 cites W2083795742 @default.
- W2057722433 cites W2087401867 @default.
- W2057722433 cites W2089403382 @default.
- W2057722433 cites W2094453711 @default.
- W2057722433 cites W2094832729 @default.
- W2057722433 cites W2101846365 @default.
- W2057722433 cites W2106306931 @default.
- W2057722433 cites W2110209356 @default.
- W2057722433 cites W2110300663 @default.
- W2057722433 cites W2111638205 @default.
- W2057722433 cites W2112963987 @default.
- W2057722433 cites W2119784457 @default.
- W2057722433 cites W2121802881 @default.
- W2057722433 cites W2124281326 @default.
- W2057722433 cites W2127220436 @default.
- W2057722433 cites W2127714237 @default.
- W2057722433 cites W2130446433 @default.
- W2057722433 cites W2132286615 @default.
- W2057722433 cites W2134205510 @default.
- W2057722433 cites W2143784594 @default.
- W2057722433 cites W2145186752 @default.
- W2057722433 cites W2145899562 @default.
- W2057722433 cites W2147471332 @default.
- W2057722433 cites W2148601705 @default.
- W2057722433 cites W2149083719 @default.
- W2057722433 cites W2154745705 @default.
- W2057722433 cites W2157523980 @default.
- W2057722433 cites W2167700185 @default.
- W2057722433 cites W2171499108 @default.
- W2057722433 cites W2172202356 @default.
- W2057722433 cites W4254088989 @default.
- W2057722433 doi "https://doi.org/10.1016/j.devbrainres.2004.03.020" @default.
- W2057722433 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15246691" @default.
- W2057722433 hasPublicationYear "2004" @default.
- W2057722433 type Work @default.
- W2057722433 sameAs 2057722433 @default.
- W2057722433 citedByCount "33" @default.
- W2057722433 countsByYear W20577224332012 @default.
- W2057722433 countsByYear W20577224332013 @default.
- W2057722433 countsByYear W20577224332014 @default.
- W2057722433 countsByYear W20577224332015 @default.