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- W2057752710 abstract "Neuroinflammation and mitochondrial dysfunction are common features of chronic neurodegenerative diseases of the central nervous system. Both conditions can lead to increased oxidative stress by excessive release of harmful reactive oxygen and nitrogen species (ROS and RNS), which further promote neuronal damage and subsequent inflammation resulting in a feed-forward loop of neurodegeneration. The cytokine tumor necrosis factor (TNF), a master regulator of the immune system, plays an important role in the propagation of inflammation due to the activation and recruitment of immune cells via its receptor TNF receptor 1 (TNFR1). Moreover, TNFR1 can directly induce oxidative stress by the activation of ROS and RNS producing enzymes. Both TNF-induced oxidative stress and inflammation interact and cooperate to promote neurodegeneration. However, TNF plays a dual role in neurodegenerative disease, since stimulation via its second receptor, TNFR2, is neuroprotective and promotes tissue regeneration. Here we review the interrelation of oxidative stress and inflammation in the two major chronic neurodegenerative diseases, Alzheimer’s and Parkinson’s disease, and discuss the dual role of TNF in promoting neurodegeneration and tissue regeneration via its two receptors." @default.
- W2057752710 created "2016-06-24" @default.
- W2057752710 creator A5036178179 @default.
- W2057752710 creator A5079347774 @default.
- W2057752710 date "2015-01-01" @default.
- W2057752710 modified "2023-10-16" @default.
- W2057752710 title "Interrelation of Oxidative Stress and Inflammation in Neurodegenerative Disease: Role of TNF" @default.
- W2057752710 cites W1491307791 @default.
- W2057752710 cites W1503511302 @default.
- W2057752710 cites W1509596990 @default.
- W2057752710 cites W1527874749 @default.
- W2057752710 cites W1535136623 @default.
- W2057752710 cites W1539544057 @default.
- W2057752710 cites W1540470728 @default.
- W2057752710 cites W1542215809 @default.
- W2057752710 cites W1582832380 @default.
- W2057752710 cites W1588992136 @default.
- W2057752710 cites W1630502818 @default.
- W2057752710 cites W1639462457 @default.
- W2057752710 cites W1672072946 @default.
- W2057752710 cites W172593691 @default.
- W2057752710 cites W1778624427 @default.
- W2057752710 cites W1822935226 @default.
- W2057752710 cites W1824123796 @default.
- W2057752710 cites W1909184393 @default.
- W2057752710 cites W1953467909 @default.
- W2057752710 cites W1965518966 @default.
- W2057752710 cites W1967291007 @default.
- W2057752710 cites W1968295892 @default.
- W2057752710 cites W1969768548 @default.
- W2057752710 cites W1969789360 @default.
- W2057752710 cites W1970606114 @default.
- W2057752710 cites W1970765576 @default.
- W2057752710 cites W1971265979 @default.
- W2057752710 cites W1971599063 @default.
- W2057752710 cites W1973362554 @default.
- W2057752710 cites W1973680986 @default.
- W2057752710 cites W1974430505 @default.
- W2057752710 cites W1976599392 @default.
- W2057752710 cites W1979867410 @default.
- W2057752710 cites W1983051953 @default.
- W2057752710 cites W1983730442 @default.
- W2057752710 cites W1986716661 @default.
- W2057752710 cites W1986876307 @default.
- W2057752710 cites W1987621178 @default.
- W2057752710 cites W1987951773 @default.
- W2057752710 cites W1990713194 @default.
- W2057752710 cites W1991128766 @default.
- W2057752710 cites W1993512907 @default.
- W2057752710 cites W1994332513 @default.
- W2057752710 cites W1994874844 @default.
- W2057752710 cites W1995508379 @default.
- W2057752710 cites W1996650387 @default.
- W2057752710 cites W1998689099 @default.
- W2057752710 cites W1998981667 @default.
- W2057752710 cites W1999882587 @default.
- W2057752710 cites W2001393747 @default.
- W2057752710 cites W2002181764 @default.
- W2057752710 cites W2003805774 @default.
- W2057752710 cites W2003827559 @default.
- W2057752710 cites W2004297047 @default.
- W2057752710 cites W2004465286 @default.
- W2057752710 cites W2004832585 @default.
- W2057752710 cites W2010466459 @default.
- W2057752710 cites W2012215271 @default.
- W2057752710 cites W2015116743 @default.
- W2057752710 cites W2016575029 @default.
- W2057752710 cites W2016695100 @default.
- W2057752710 cites W2017003937 @default.
- W2057752710 cites W2017228357 @default.
- W2057752710 cites W2018076136 @default.
- W2057752710 cites W2018427017 @default.
- W2057752710 cites W2019022238 @default.
- W2057752710 cites W2022687465 @default.
- W2057752710 cites W2022827044 @default.
- W2057752710 cites W2024306318 @default.
- W2057752710 cites W2026517317 @default.
- W2057752710 cites W2027574725 @default.
- W2057752710 cites W2027649342 @default.
- W2057752710 cites W2028151158 @default.
- W2057752710 cites W2028705859 @default.
- W2057752710 cites W2029503696 @default.
- W2057752710 cites W2030816101 @default.
- W2057752710 cites W2033832481 @default.
- W2057752710 cites W2035421145 @default.
- W2057752710 cites W2035787181 @default.
- W2057752710 cites W2036411709 @default.
- W2057752710 cites W2036671631 @default.
- W2057752710 cites W2037043234 @default.
- W2057752710 cites W2038729399 @default.
- W2057752710 cites W2038780435 @default.
- W2057752710 cites W2040536037 @default.
- W2057752710 cites W2041358315 @default.
- W2057752710 cites W2042045241 @default.
- W2057752710 cites W2042433922 @default.
- W2057752710 cites W2047402066 @default.
- W2057752710 cites W2047402578 @default.
- W2057752710 cites W2048339025 @default.