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• W2057757045 abstract "Objective Human burn injury is associated with an inflammatory response and related hyperdynamic cardiovascular profile. Increased production of nitric oxide (NO), a potent endogenous vasodilator, has been reported in patients with inflammatory states, including sepsis, but not after trauma other than burns. We studied whether plasma levels of the stable byproducts of NO, nitrite (NO2 sup -) and nitrate (NO3 sup -), are increased in burn patients. Design Prospective controlled study. Patients and Methods In consecutive patients admitted to the intensive care unit of the burn center at the Queen Astrid Military Hospital in Brussels, plasma was drawn daily from day 1 to day 5 postadmission for determination of NO2 sup - -/NO3 sup - levels (Griess' reaction). In a control group of nonseptic inpatients from the department of neurology in Erasme University Hospital who were matched for nutrition (30 to 40 kcal/kg/day of a standard enteral solution), plasma was drawn once for NO2 sup - /NO3 sup - determination. Measurements and Main Results The burn group included 16 patients (age 35 +/- 18 years, total burn surface area (TBSA) 37 +/- 19%) and the control group included six patients (age 64 +/- 18 years). For each comparison between the groups, NO2 sup - /NO3 sup - plasma levels were higher in those patients with burns than in the control group. In the burn group, there was no correlation between NO2 sup - /NO3 sup - plasma levels and TBSA, age, TBSA X age, blood pressure or time. However, in a subgroup of five burned patients who became septic during the study period, NO2 sup - /NO3 sup - plasma levels were slightly higher than in the noninfected patients (177 +/- 131 vs. 83 +/- 48 micromoles/L, NS) Conclusion Human burn injury is associated with an increase in NO production. In this small-size study, NO production was not proportional to burn area, and seemed to be further enhanced in septic patients." @default.
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• W2057757045 date "1996-03-01" @default.
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• W2057757045 title "Nitric Oxide Production Is Increased in Patients after Burn Injury" @default.
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• W2057757045 doi "https://doi.org/10.1097/00005373-199603000-00007" @default.
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