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- W2057777105 abstract "Significance Rab8 is a key regulator of exocytosis. To understand how Rab8 itself is regulated in cells, it is pivotal to study how its guanine nucleotide exchange factor (GEF) Rabin8 is activated. Here we demonstrate that Rabin8 has an autoinhibitory conformation. Phosphorylation of Rabin8 by ERK1/2 in response to EGF relieves the autoinhibition of Rabin8, thus promoting its GEF activity on Rab8. In cells, blocking Rabin8 phosphorylation inhibits vesicular trafficking to the plasma membrane. Our work identifies a molecular mechanism for Rabin8 activation and reveals a regulatory pathway that controls Rab8 activation and vesicular trafficking in response to extracellular signaling." @default.
- W2057777105 created "2016-06-24" @default.
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- W2057777105 date "2014-12-22" @default.
- W2057777105 modified "2023-10-05" @default.
- W2057777105 title "Activation of Rab8 guanine nucleotide exchange factor Rabin8 by ERK1/2 in response to EGF signaling" @default.
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- W2057777105 doi "https://doi.org/10.1073/pnas.1412089112" @default.
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