FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2057777692> ?p ?o ?g. }

• W2057777692 endingPage "28646" @default.
• W2057777692 startingPage "28642" @default.
• W2057777692 abstract "Reverse transcriptases from both human immunodeficiency viruses type 1 and 2 are obligatory dimers. A tryptophan-rich repeat motif that is highly conserved between these proteins, as well as in the reverse transcriptase from simian immunodeficiency virus, has been postulated to be involved in hydrophobic subunit interactions. A synthetic 19-mer peptide covering part of this tryptophan repeat motif was recently shown to inhibit human immunodeficiency viruses type 1 reverse transcriptase subunit dimerization (Divita, G., Restle, T., Goody, R. S., Chermann, J.-C., and Baillon, J. G.(1994) J. Biol. Chem. 269, 13080-13083). In the present study, we show that the same peptide can also inhibit human immunodeficiency virus type 2 reverse transcriptase subunit dimerization, suggesting that the same inhibitors might be used as agents against both viruses as well as against variants of human immunodeficiency virus type 1 that differ from the variant against which they were developed. Under appropriate experimental conditions, e.g. at acidic pH, this peptide is also able to induce the dissociation of the enzyme from human immunodeficiency virus type 1. Reverse transcriptases from both human immunodeficiency viruses type 1 and 2 are obligatory dimers. A tryptophan-rich repeat motif that is highly conserved between these proteins, as well as in the reverse transcriptase from simian immunodeficiency virus, has been postulated to be involved in hydrophobic subunit interactions. A synthetic 19-mer peptide covering part of this tryptophan repeat motif was recently shown to inhibit human immunodeficiency viruses type 1 reverse transcriptase subunit dimerization (Divita, G., Restle, T., Goody, R. S., Chermann, J.-C., and Baillon, J. G.(1994) J. Biol. Chem. 269, 13080-13083). In the present study, we show that the same peptide can also inhibit human immunodeficiency virus type 2 reverse transcriptase subunit dimerization, suggesting that the same inhibitors might be used as agents against both viruses as well as against variants of human immunodeficiency virus type 1 that differ from the variant against which they were developed. Under appropriate experimental conditions, e.g. at acidic pH, this peptide is also able to induce the dissociation of the enzyme from human immunodeficiency virus type 1." @default.
• W2057777692 created "2016-06-24" @default.
• W2057777692 creator A5008360495 @default.
• W2057777692 creator A5040210151 @default.
• W2057777692 creator A5051146400 @default.
• W2057777692 creator A5051625670 @default.
• W2057777692 creator A5057982935 @default.
• W2057777692 date "1995-12-01" @default.
• W2057777692 modified "2023-10-17" @default.
• W2057777692 title "Interface Peptides as Structure-based Human Immunodeficiency Virus Reverse Transcriptase Inhibitors" @default.
• W2057777692 cites W1497536572 @default.
• W2057777692 cites W1507986200 @default.
• W2057777692 cites W1512060784 @default.
• W2057777692 cites W1547738547 @default.
• W2057777692 cites W1581989954 @default.
• W2057777692 cites W1584412432 @default.
• W2057777692 cites W1594741329 @default.
• W2057777692 cites W1602911429 @default.
• W2057777692 cites W1964007399 @default.
• W2057777692 cites W1984430631 @default.
• W2057777692 cites W2004832262 @default.
• W2057777692 cites W2008954911 @default.
• W2057777692 cites W2009581957 @default.
• W2057777692 cites W2009722734 @default.
• W2057777692 cites W2011153626 @default.
• W2057777692 cites W2027601754 @default.
• W2057777692 cites W2028027213 @default.
• W2057777692 cites W2028143521 @default.
• W2057777692 cites W2038311079 @default.
• W2057777692 cites W2046134251 @default.
• W2057777692 cites W2050267656 @default.
• W2057777692 cites W2065740427 @default.
• W2057777692 cites W2090126383 @default.
• W2057777692 cites W2090883394 @default.
• W2057777692 cites W2092786021 @default.
• W2057777692 cites W2102098015 @default.
• W2057777692 cites W2124217674 @default.
• W2057777692 cites W2128508248 @default.
• W2057777692 cites W4293247451 @default.
• W2057777692 doi "https://doi.org/10.1074/jbc.270.48.28642" @default.
• W2057777692 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7499382" @default.
• W2057777692 hasPublicationYear "1995" @default.
• W2057777692 type Work @default.
• W2057777692 sameAs 2057777692 @default.
• W2057777692 citedByCount "29" @default.
• W2057777692 countsByYear W20577776922013 @default.
• W2057777692 countsByYear W20577776922016 @default.
• W2057777692 countsByYear W20577776922019 @default.
• W2057777692 crossrefType "journal-article" @default.
• W2057777692 hasAuthorship W2057777692A5008360495 @default.
• W2057777692 hasAuthorship W2057777692A5040210151 @default.
• W2057777692 hasAuthorship W2057777692A5051146400 @default.
• W2057777692 hasAuthorship W2057777692A5051625670 @default.
• W2057777692 hasAuthorship W2057777692A5057982935 @default.
• W2057777692 hasBestOaLocation W20577776921 @default.
• W2057777692 hasConcept C104292427 @default.
• W2057777692 hasConcept C104317684 @default.
• W2057777692 hasConcept C153911025 @default.
• W2057777692 hasConcept C156719811 @default.
• W2057777692 hasConcept C159047783 @default.
• W2057777692 hasConcept C2522874641 @default.
• W2057777692 hasConcept C2776706248 @default.
• W2057777692 hasConcept C2777995582 @default.
• W2057777692 hasConcept C2779281246 @default.
• W2057777692 hasConcept C515207424 @default.
• W2057777692 hasConcept C55493867 @default.
• W2057777692 hasConcept C67705224 @default.
• W2057777692 hasConcept C86803240 @default.
• W2057777692 hasConceptScore W2057777692C104292427 @default.
• W2057777692 hasConceptScore W2057777692C104317684 @default.
• W2057777692 hasConceptScore W2057777692C153911025 @default.
• W2057777692 hasConceptScore W2057777692C156719811 @default.
• W2057777692 hasConceptScore W2057777692C159047783 @default.
• W2057777692 hasConceptScore W2057777692C2522874641 @default.
• W2057777692 hasConceptScore W2057777692C2776706248 @default.
• W2057777692 hasConceptScore W2057777692C2777995582 @default.
• W2057777692 hasConceptScore W2057777692C2779281246 @default.
• W2057777692 hasConceptScore W2057777692C515207424 @default.
• W2057777692 hasConceptScore W2057777692C55493867 @default.
• W2057777692 hasConceptScore W2057777692C67705224 @default.
• W2057777692 hasConceptScore W2057777692C86803240 @default.
• W2057777692 hasIssue "48" @default.
• W2057777692 hasLocation W20577776921 @default.
• W2057777692 hasOpenAccess W2057777692 @default.
• W2057777692 hasPrimaryLocation W20577776921 @default.
• W2057777692 hasRelatedWork W1522685369 @default.
• W2057777692 hasRelatedWork W2079860770 @default.
• W2057777692 hasRelatedWork W2089024433 @default.
• W2057777692 hasRelatedWork W2092897512 @default.
• W2057777692 hasRelatedWork W2119281094 @default.
• W2057777692 hasRelatedWork W2392315405 @default.
• W2057777692 hasRelatedWork W2421823763 @default.
• W2057777692 hasRelatedWork W2423942488 @default.
• W2057777692 hasRelatedWork W2564874675 @default.
• W2057777692 hasRelatedWork W656753012 @default.
• W2057777692 hasVolume "270" @default.
• W2057777692 isParatext "false" @default.
• W2057777692 isRetracted "false" @default.

• next