Matches in SemOpenAlex for { <https://semopenalex.org/work/W2057777794> ?p ?o ?g. }
Showing items 1 to 84 of
84
with 100 items per page.
- W2057777794 endingPage "578" @default.
- W2057777794 startingPage "573" @default.
- W2057777794 abstract "The Notch pathway is an intercellular signaling mechanism frequently used for controlling cell fate during organogenesis. There are four structurally related Notch receptors in mice and humans, and Notch1 and Notch2 are essential genes. In this report we describe the construction of a transgenic mouse strain that expresses the Notch2 intracellular domain in response to cell lineage specific expression of Cre recombinase. This approach bypasses the requirement for ligand- receptor interaction and allows the direct determination of the consequences of Notch2 activation in vivo. Exogenous expression of the Notch2 intracellular domain resulted in the developmental arrest of secondary heart field derived cardiomyocytes during the transition from immature α-Smooth Muscle Actin expressing cells to mature α-Actinin positive cardiomyocytes. In contrast, a cell nonautonomous mesenchymal expansion was observed in semilunar valves. This new conditionally expressed allele of Notch2 can be used in studies by investigators interested in the effects of Notch2 activation in vivo. genesis, 47:573–578, 2009. Published 2009 Wiley-Liss, Inc." @default.
- W2057777794 created "2016-06-24" @default.
- W2057777794 creator A5026079925 @default.
- W2057777794 creator A5041507379 @default.
- W2057777794 creator A5061847728 @default.
- W2057777794 date "2009-08-01" @default.
- W2057777794 modified "2023-09-25" @default.
- W2057777794 title "Generation of mice that conditionally express the activation domain of Notch2" @default.
- W2057777794 cites W1660631781 @default.
- W2057777794 cites W1768274470 @default.
- W2057777794 cites W1965271063 @default.
- W2057777794 cites W1965963514 @default.
- W2057777794 cites W1966828612 @default.
- W2057777794 cites W1971510012 @default.
- W2057777794 cites W1993862102 @default.
- W2057777794 cites W2013933388 @default.
- W2057777794 cites W2025748388 @default.
- W2057777794 cites W2034288900 @default.
- W2057777794 cites W2034454142 @default.
- W2057777794 cites W2035288932 @default.
- W2057777794 cites W2065528851 @default.
- W2057777794 cites W2075401648 @default.
- W2057777794 cites W2095666604 @default.
- W2057777794 cites W2101676313 @default.
- W2057777794 cites W2110661078 @default.
- W2057777794 cites W2139814462 @default.
- W2057777794 cites W2145832243 @default.
- W2057777794 cites W2150438590 @default.
- W2057777794 cites W2164369044 @default.
- W2057777794 doi "https://doi.org/10.1002/dvg.20537" @default.
- W2057777794 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19530136" @default.
- W2057777794 hasPublicationYear "2009" @default.
- W2057777794 type Work @default.
- W2057777794 sameAs 2057777794 @default.
- W2057777794 citedByCount "3" @default.
- W2057777794 countsByYear W20577777942012 @default.
- W2057777794 crossrefType "journal-article" @default.
- W2057777794 hasAuthorship W2057777794A5026079925 @default.
- W2057777794 hasAuthorship W2057777794A5041507379 @default.
- W2057777794 hasAuthorship W2057777794A5061847728 @default.
- W2057777794 hasConcept C102230213 @default.
- W2057777794 hasConcept C104317684 @default.
- W2057777794 hasConcept C161879069 @default.
- W2057777794 hasConcept C163952510 @default.
- W2057777794 hasConcept C170493617 @default.
- W2057777794 hasConcept C54355233 @default.
- W2057777794 hasConcept C62478195 @default.
- W2057777794 hasConcept C79879829 @default.
- W2057777794 hasConcept C86339819 @default.
- W2057777794 hasConcept C86803240 @default.
- W2057777794 hasConcept C95444343 @default.
- W2057777794 hasConceptScore W2057777794C102230213 @default.
- W2057777794 hasConceptScore W2057777794C104317684 @default.
- W2057777794 hasConceptScore W2057777794C161879069 @default.
- W2057777794 hasConceptScore W2057777794C163952510 @default.
- W2057777794 hasConceptScore W2057777794C170493617 @default.
- W2057777794 hasConceptScore W2057777794C54355233 @default.
- W2057777794 hasConceptScore W2057777794C62478195 @default.
- W2057777794 hasConceptScore W2057777794C79879829 @default.
- W2057777794 hasConceptScore W2057777794C86339819 @default.
- W2057777794 hasConceptScore W2057777794C86803240 @default.
- W2057777794 hasConceptScore W2057777794C95444343 @default.
- W2057777794 hasIssue "8" @default.
- W2057777794 hasLocation W20577777941 @default.
- W2057777794 hasLocation W20577777942 @default.
- W2057777794 hasOpenAccess W2057777794 @default.
- W2057777794 hasPrimaryLocation W20577777941 @default.
- W2057777794 hasRelatedWork W1966828612 @default.
- W2057777794 hasRelatedWork W2142916161 @default.
- W2057777794 hasRelatedWork W2169979796 @default.
- W2057777794 hasRelatedWork W2379182815 @default.
- W2057777794 hasRelatedWork W2394502857 @default.
- W2057777794 hasRelatedWork W2489528588 @default.
- W2057777794 hasRelatedWork W2766804293 @default.
- W2057777794 hasRelatedWork W3112309590 @default.
- W2057777794 hasRelatedWork W4200503280 @default.
- W2057777794 hasRelatedWork W180032050 @default.
- W2057777794 hasVolume "47" @default.
- W2057777794 isParatext "false" @default.
- W2057777794 isRetracted "false" @default.
- W2057777794 magId "2057777794" @default.
- W2057777794 workType "article" @default.