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• W2057783610 abstract "Abstract Background: High intake of folate, vitamin B6, and vitamin B12 have been hypothesized to lower the risk for breast cancer. We conducted a population-based case-control study to evaluate the risk for breast cancer among Mexican women with relatively low vitamin intakes. Methods: We included 475 women (median age, 53 years; range, 23-87 years) diagnosed with incident breast cancer through six hospitals in Mexico City and interviewed them to obtain data on breast cancer risk factors and their usual diet using a food frequency questionnaire. We selected 1,391 (median age, 49 years; range, 18-82 years) controls from the Mexico City population using a national sampling frame. Results: Compared with women in the lowest quartile, the odds ratio for breast cancer for women in the highest quartile of folate intake was 0.64 [95% confidence intervals (CI), 0.45-0.90; P, test for trend = 0.009] and 0.32 (95% CI, 0.22-0.49; P, test for trend &lt; 0.0001) for vitamin B12 intake. Among postmenopausal women, intakes of folate and vitamin B12 were associated with a lower risk of breast cancer and those associations were stronger than among premenopausal women. The inverse association of folate and breast cancer was stronger among women who consumed a high level of vitamin B12 as compared with women consuming diets low in vitamin B12. No association was observed for vitamin B6 intake. Conclusions: In this population, high intakes of folate and vitamin B12 were independently associated with decreased breast cancer risk, particularly among postmenopausal women. (Cancer Epidemiol Biomarkers Prev 2006;15(3):443–8)" @default.
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• W2057783610 date "2006-03-01" @default.
• W2057783610 modified "2023-09-23" @default.
• W2057783610 title "Folate, Vitamin B6, and Vitamin B12 Intake and the Risk of Breast Cancer Among Mexican Women" @default.
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• W2057783610 doi "https://doi.org/10.1158/1055-9965.epi-05-0532" @default.
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