Matches in SemOpenAlex for { <https://semopenalex.org/work/W2057784185> ?p ?o ?g. }
- W2057784185 endingPage "207" @default.
- W2057784185 startingPage "193" @default.
- W2057784185 abstract "Abstract Extracellular nucleotide stimulation of purinergic/pyrimidinergic type‐2 (P2) receptors are components of platelet, endothelial cell (EC), and leukocyte activation that culminate in vascular thrombosis and inflammation in vivo. CD39, the prototype nucleoside triphosphate diphosphohydrolase (or NTPDase‐1), is highly expressed on quiescent endothelium, monocytes, and activated lymphocytes and therefore could influence these pathways. The potential of NTPDase‐1 to regulate P2‐receptor function in the vasculature has been established by our generation of cd39 ‐null mice. These mice exhibit a prothrombotic vascular phenotype ascribed to overexpression of tissue factor by endothelial cells following aberrant P2‐ (and potentially adenosine 2a/3) receptor activation. Mutant mice also show perturbations in hemostasis, secondary to platelet P2Y1‐receptor desensitization. In addition, administration of soluble NTPDase and/or induction of CD39 overexpression by adenoviral vectors consistently result in amelioration of vascular injury in several animal models tested. CD39 is also the major NTPDase expressed by monocyte‐macrophages (Mo). Upregulation of tissue factor expression by Mo in vitro and alterations in splenic populations in vivo have been observed in cd39 ‐null mice. Paradoxical inhibition of integrin‐mediated adhesion and transendothelial migration of cd39 ‐null Mo are also related to aberrant P2‐receptor activation and have also been observed in vitro and in vivo. Overexpression of CD39 following infection with recombinant adenoviral vectors also blocks LPS‐induced ATP secretion and inhibits IL‐1 release in vitro. These studies confirm a role for CD39 in the differential regulation of P2‐receptor activity and function in platelets, vascular, and immune cells. Drug Dev. Res. 53:193–207, 2001. © 2001 Wiley‐Liss, Inc." @default.
- W2057784185 created "2016-06-24" @default.
- W2057784185 creator A5012426113 @default.
- W2057784185 creator A5012615383 @default.
- W2057784185 creator A5019777904 @default.
- W2057784185 creator A5022448257 @default.
- W2057784185 creator A5041621533 @default.
- W2057784185 creator A5048205079 @default.
- W2057784185 creator A5050854410 @default.
- W2057784185 creator A5053929827 @default.
- W2057784185 date "2001-06-01" @default.
- W2057784185 modified "2023-10-18" @default.
- W2057784185 title "Modulation of extracellular nucleotide-mediated signaling by CD39/nucleoside triphosphate diphosphohydrolase-1" @default.
- W2057784185 cites W1258111398 @default.
- W2057784185 cites W132642117 @default.
- W2057784185 cites W1491069537 @default.
- W2057784185 cites W1492226152 @default.
- W2057784185 cites W1501783126 @default.
- W2057784185 cites W1519102962 @default.
- W2057784185 cites W1519164650 @default.
- W2057784185 cites W1522010565 @default.
- W2057784185 cites W1565215613 @default.
- W2057784185 cites W1565285014 @default.
- W2057784185 cites W1567363998 @default.
- W2057784185 cites W1574019333 @default.
- W2057784185 cites W1579348184 @default.
- W2057784185 cites W1792542720 @default.
- W2057784185 cites W1811799314 @default.
- W2057784185 cites W1815757713 @default.
- W2057784185 cites W1832045131 @default.
- W2057784185 cites W1870523313 @default.
- W2057784185 cites W1918855189 @default.
- W2057784185 cites W1957977306 @default.
- W2057784185 cites W1963877462 @default.
- W2057784185 cites W1964835089 @default.
- W2057784185 cites W1970170503 @default.
- W2057784185 cites W1972546896 @default.
- W2057784185 cites W1974204965 @default.
- W2057784185 cites W1974218803 @default.
- W2057784185 cites W1976342357 @default.
- W2057784185 cites W1978920096 @default.
- W2057784185 cites W1979950065 @default.
- W2057784185 cites W1981871034 @default.
- W2057784185 cites W1983577961 @default.
- W2057784185 cites W1984603218 @default.
- W2057784185 cites W1985129704 @default.
- W2057784185 cites W1989866518 @default.
- W2057784185 cites W1990517683 @default.
- W2057784185 cites W1997076203 @default.
- W2057784185 cites W1997888150 @default.
- W2057784185 cites W1998865212 @default.
- W2057784185 cites W1999271438 @default.
- W2057784185 cites W2000095972 @default.
- W2057784185 cites W2002451448 @default.
- W2057784185 cites W2003910580 @default.
- W2057784185 cites W2004169572 @default.
- W2057784185 cites W2004696602 @default.
- W2057784185 cites W2005856601 @default.
- W2057784185 cites W2007472940 @default.
- W2057784185 cites W2008054762 @default.
- W2057784185 cites W2010073489 @default.
- W2057784185 cites W2011492906 @default.
- W2057784185 cites W2012510435 @default.
- W2057784185 cites W2014023264 @default.
- W2057784185 cites W2014235031 @default.
- W2057784185 cites W2014959551 @default.
- W2057784185 cites W2016217548 @default.
- W2057784185 cites W2016757139 @default.
- W2057784185 cites W2018204952 @default.
- W2057784185 cites W2018934217 @default.
- W2057784185 cites W2023204231 @default.
- W2057784185 cites W2025660491 @default.
- W2057784185 cites W2027439509 @default.
- W2057784185 cites W2032238406 @default.
- W2057784185 cites W2033102468 @default.
- W2057784185 cites W2033580900 @default.
- W2057784185 cites W2033981667 @default.
- W2057784185 cites W2033999776 @default.
- W2057784185 cites W2034910724 @default.
- W2057784185 cites W2036029448 @default.
- W2057784185 cites W2036750318 @default.
- W2057784185 cites W2038370680 @default.
- W2057784185 cites W2040797703 @default.
- W2057784185 cites W2041611018 @default.
- W2057784185 cites W2043638000 @default.
- W2057784185 cites W2044014719 @default.
- W2057784185 cites W2045074917 @default.
- W2057784185 cites W2045680940 @default.
- W2057784185 cites W2046425380 @default.
- W2057784185 cites W2050541052 @default.
- W2057784185 cites W2051148897 @default.
- W2057784185 cites W2053246203 @default.
- W2057784185 cites W2056580837 @default.
- W2057784185 cites W2058768349 @default.
- W2057784185 cites W2068624858 @default.
- W2057784185 cites W2070280898 @default.
- W2057784185 cites W2075771764 @default.
- W2057784185 cites W2075865032 @default.