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• W2057788173 abstract "D1 and D2 dopamine receptors exert synergistic effects on the firing rates of basal ganglia neurons and on the expression of stereotyped behavior in rats. Moreover, the ability of D2 agonists to induce changes in basal ganglia single unit activity and spontaneous motor activity is dependent upon the presence of endogenous dopamine to stimulate D1 receptors; in rats treated with alpha-methyl-rho-tyrosine to reduce endogenous dopamine levels, the neurophysiological and behavioral effects of the D2 agonist quinpirole are significantly attenuated, while the effects of nonselective agonists like apomorphine, which stimulate both D1 and D2 receptors, or combinations of a D2 agonist and a D1 agonist are not attenuated. Thus, the previously held view that D2 receptors alone are responsible for evoking the changes in behavior and basal ganglia output induced by nonselective dopamine agonists and endogenous dopamine is not supported by these results, which indicate that these phenomena require concurrent stimulation of both dopamine receptor subtypes." @default.
• W2057788173 created "2016-06-24" @default.
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• W2057788173 date "1987-05-08" @default.
• W2057788173 modified "2023-10-18" @default.
• W2057788173 title "D ₁ Dopamine Receptor Activation Required for Postsynaptic Expression of D ₂ Agonist Effects" @default.
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• W2057788173 doi "https://doi.org/10.1126/science.2953072" @default.
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