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• W2057788258 abstract "The thrombotic microangiopathies, which include thrombotic thrombocytopenic purpura and hemolytic-uremic syndrome, cause microangiopathic hemolytic anemia, thrombocytopenia, and ischemic events due to the presence of microvascular occlusive platelet thrombi. 1 Moake J.L. Thrombotic microangiopathies. N Engl J Med. 2002; 347: 589-600 Crossref PubMed Scopus (1148) Google Scholar Associated mortality exceeded 90% before the introduction of plasma exchange therapy in the 1970s and still remains as high as 20%. 2 Elliott M.A. Nichols W.L. Thrombotic thrombocytopenic purpura and hemolytic uremic syndrome. Mayo Clin Proc. 2001; 76: 1154-1162 Abstract Full Text Full Text PDF PubMed Scopus (81) Google Scholar Based on our clinical experience, we hypothesized that high mortality may be partly due to development of heart failure. However, symptomatic cardiac involvement in patients with thrombotic microangiopathies is infrequently reported despite pathological studies demonstrating cardiac microthrombi. 3 Berkowitz L.R. Dalldor F.G. Blatt P. Thrombotic thrombocytopenic purpura a pathology review. JAMA. 1979; 241: 1709-1710 Crossref PubMed Scopus (55) Google Scholar , 4 Cuttner J. Thrombotic thrombocytopenic purpura a ten-year experience. Blood. 1980; 56: 302-306 PubMed Google Scholar , 5 Eagle K.A. Fallon J.T. Weekly clinicopathological exercises: case 33-1994: A 41-year-old woman with thrombocytopenia, anemia, and sudden death. N Engl J Med. 1994; 331: 661-667 Crossref PubMed Scopus (15) Google Scholar , 6 Ridolfi R.L. Hutchins G.M. Bell W.R. The heart and cardiac conduction system in thrombotic thrombocytopenic purpura. Ann Intern Med. 1979; 91: 357-363 Crossref PubMed Scopus (81) Google Scholar , 7 Ridolfi R.L. Bell W.R. Thrombotic thrombocytopenic purpura report of 25 cases and review of the literature. Medicine. 1981; 60: 413-428 Crossref PubMed Scopus (392) Google Scholar The aims of this study were to determine the incidence of acute heart failure in adults with thrombotic microangiopathies, its natural history, severity and reversibility of systolic dysfunction, and associated mortality rate." @default.
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• W2057788258 date "2005-05-01" @default.
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• W2057788258 title "Incidence and prognosis of acute heart failure in the thrombotic microangiopathies" @default.
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• W2057788258 doi "https://doi.org/10.1016/j.amjmed.2005.02.019" @default.
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