Matches in SemOpenAlex for { <https://semopenalex.org/work/W2057788460> ?p ?o ?g. }
- W2057788460 endingPage "64" @default.
- W2057788460 startingPage "55" @default.
- W2057788460 abstract "In Staphylococcus aureus, biofilm formation can be associated with the production of surface-anchored proteins, including Bap, SasG, FnBPs or Spa. By mutational analysis, and using a model strain in which biofilm formation was Bap-dependent, we found that σB was essential for protein-dependent biofilm development. Non-polar mutations of σB in genetically unrelated S. aureus strains lowered the Bap expression and completely impaired biofilm development. Although Northern blot analysis showed a slight reduction in bap transcription, we demonstrated that Aur and SspA, two proteases that are overexpressed in the sigB mutant strain and are capable of degrading Bap, inhibit biofilm formation. Interestingly, a double sigB–agr mutant, which showed a diminished capacity to express extracellular proteases, was able to restore biofilm formation. Since the vast majority of the S. aureus global regulators control the expression of the extracellular proteases, the results of this work demonstrate the existence of a new pathway controlling protein-mediated biofilm formation in which different global regulators modulate biofilm formation by controlling the expression of S. aureus extracellular proteases." @default.
- W2057788460 created "2016-06-24" @default.
- W2057788460 creator A5025787966 @default.
- W2057788460 creator A5031330992 @default.
- W2057788460 creator A5061237846 @default.
- W2057788460 creator A5071346312 @default.
- W2057788460 creator A5073273932 @default.
- W2057788460 creator A5082360434 @default.
- W2057788460 creator A5083911093 @default.
- W2057788460 date "2010-01-01" @default.
- W2057788460 modified "2023-10-16" @default.
- W2057788460 title "Extracellular proteases inhibit protein-dependent biofilm formation in Staphylococcus aureus" @default.
- W2057788460 cites W1513363708 @default.
- W2057788460 cites W1549916905 @default.
- W2057788460 cites W1967377218 @default.
- W2057788460 cites W1970783326 @default.
- W2057788460 cites W1978163337 @default.
- W2057788460 cites W1987400078 @default.
- W2057788460 cites W2009912226 @default.
- W2057788460 cites W2014399796 @default.
- W2057788460 cites W2041929490 @default.
- W2057788460 cites W2051578289 @default.
- W2057788460 cites W2062128984 @default.
- W2057788460 cites W2062691302 @default.
- W2057788460 cites W2079602979 @default.
- W2057788460 cites W2084622748 @default.
- W2057788460 cites W2088726933 @default.
- W2057788460 cites W2102361871 @default.
- W2057788460 cites W2106538205 @default.
- W2057788460 cites W2106553411 @default.
- W2057788460 cites W2111186812 @default.
- W2057788460 cites W2117856126 @default.
- W2057788460 cites W2120735676 @default.
- W2057788460 cites W2122020611 @default.
- W2057788460 cites W2122158062 @default.
- W2057788460 cites W2127498551 @default.
- W2057788460 cites W2129662996 @default.
- W2057788460 cites W2131960239 @default.
- W2057788460 cites W2136989595 @default.
- W2057788460 cites W2142414718 @default.
- W2057788460 cites W2145489399 @default.
- W2057788460 cites W2149299339 @default.
- W2057788460 cites W2153453937 @default.
- W2057788460 cites W2155419526 @default.
- W2057788460 cites W2155656709 @default.
- W2057788460 cites W2157220975 @default.
- W2057788460 cites W2159481897 @default.
- W2057788460 cites W2160921972 @default.
- W2057788460 cites W2162202488 @default.
- W2057788460 cites W2170113031 @default.
- W2057788460 cites W2171688147 @default.
- W2057788460 doi "https://doi.org/10.1016/j.micinf.2009.10.005" @default.
- W2057788460 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19883788" @default.
- W2057788460 hasPublicationYear "2010" @default.
- W2057788460 type Work @default.
- W2057788460 sameAs 2057788460 @default.
- W2057788460 citedByCount "106" @default.
- W2057788460 countsByYear W20577884602012 @default.
- W2057788460 countsByYear W20577884602013 @default.
- W2057788460 countsByYear W20577884602014 @default.
- W2057788460 countsByYear W20577884602015 @default.
- W2057788460 countsByYear W20577884602016 @default.
- W2057788460 countsByYear W20577884602017 @default.
- W2057788460 countsByYear W20577884602018 @default.
- W2057788460 countsByYear W20577884602019 @default.
- W2057788460 countsByYear W20577884602020 @default.
- W2057788460 countsByYear W20577884602021 @default.
- W2057788460 countsByYear W20577884602022 @default.
- W2057788460 countsByYear W20577884602023 @default.
- W2057788460 crossrefType "journal-article" @default.
- W2057788460 hasAuthorship W2057788460A5025787966 @default.
- W2057788460 hasAuthorship W2057788460A5031330992 @default.
- W2057788460 hasAuthorship W2057788460A5061237846 @default.
- W2057788460 hasAuthorship W2057788460A5071346312 @default.
- W2057788460 hasAuthorship W2057788460A5073273932 @default.
- W2057788460 hasAuthorship W2057788460A5082360434 @default.
- W2057788460 hasAuthorship W2057788460A5083911093 @default.
- W2057788460 hasBestOaLocation W20577884602 @default.
- W2057788460 hasConcept C104317684 @default.
- W2057788460 hasConcept C143065580 @default.
- W2057788460 hasConcept C181199279 @default.
- W2057788460 hasConcept C182220744 @default.
- W2057788460 hasConcept C189165786 @default.
- W2057788460 hasConcept C2776415932 @default.
- W2057788460 hasConcept C2779489039 @default.
- W2057788460 hasConcept C28406088 @default.
- W2057788460 hasConcept C523546767 @default.
- W2057788460 hasConcept C54355233 @default.
- W2057788460 hasConcept C55493867 @default.
- W2057788460 hasConcept C58123911 @default.
- W2057788460 hasConcept C86803240 @default.
- W2057788460 hasConcept C89423630 @default.
- W2057788460 hasConcept C95444343 @default.
- W2057788460 hasConceptScore W2057788460C104317684 @default.
- W2057788460 hasConceptScore W2057788460C143065580 @default.
- W2057788460 hasConceptScore W2057788460C181199279 @default.
- W2057788460 hasConceptScore W2057788460C182220744 @default.
- W2057788460 hasConceptScore W2057788460C189165786 @default.