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• W2057788658 abstract "Free AccessNicotineNarcolepsy with Cataplexy Masked by the Use of Nicotine Matthew R. Ebben, Ph.D., Ana C. Krieger, M.D., M.P.H. Matthew R. Ebben, Ph.D. Address correspondence to: Matthew R. Ebben, Ph.D., Center for Sleep Medicine, Weill Cornell Medical College, 425 East 61st Street, 5th Floor, New York, NY 10065(646) 962-9313(646) 962-0455 E-mail Address: [email protected] Department of Neurology and Neuroscience, Division of Pulmonary and Critical Care Medicine, Weill Cornell Medical College, New York, NY Search for more papers by this author , Ana C. Krieger, M.D., M.P.H. Department of Neurology and Neuroscience, Division of Pulmonary and Critical Care Medicine, Weill Cornell Medical College, New York, NY Department of Medicine, Weill Cornell Medical College, New York, NY Search for more papers by this author Published Online:April 15, 2012https://doi.org/10.5664/jcsm.1780Cited by:5SectionsAbstractPDF ShareShare onFacebookTwitterLinkedInRedditEmail ToolsAdd to favoritesDownload CitationsTrack Citations AboutABSTRACTThis report describes a case of narcolepsy with cataplexy masked by the chronic use of cigarettes and nicotine patches. It has been described that narcoleptic smokers report relief of symptoms by smoking tobacco cigarettes.1 In addition, a case describing partial treatment of sleepiness using a nicotine patch in an adolescent with narcolepsy was recently reported in this journal.2 Our case adds to the growing literature that nicotine may be used to manage symptoms associated with narcolepsy.Citation:Ebben MR; Krieger AC. Narcolepsy with cataplexy masked by the use of nicotine. J Clin Sleep Med 2012;8(2):195-196.INTRODUCTIONNarcolepsy is thought to be a disorder of REM sleep, with cataplexy representing episodes of REM-related muscle atonia intruding into the waking period. Narcoleptics often report episodes of dreaming during daytime naps, and the diagnosis of narcolepsy is based in part on a mean sleep latency ≤ 8 min with ≥ 2 REM sleep episodes on naps administered during a daytime multiple sleep latency test (MSLT). REM sleep is partially produced by cholinergic activation of the thalamus, and muscle atonia during REM sleep is triggered by the cholinergic effect on the medial medulla.3,4 Both nicotinic and muscarinic agonists, as well as acetylcholinesterase inhibitors, have been shown to increase REM sleep.5–7 Interestingly, although low levels of nicotine administration have been shown to increase REM sleep, high levels of nicotine seem to reduce REM sleep percentage and decrease total sleep time in both animals and humans.8Of interest in our current case, transdermal nicotine patches in nonsmokers have been shown to reduce REM sleep percentage and decrease total sleep time.9,10 In addition, REM rebound has been shown after stopping nicotine.10,11REPORT OF CASEThe current case involves an 89-year-old female referred for evaluation of cataplexy-like episodes. The patient describes having infrequent episodes of cataplexy for several years, described as a sensation of temporary loss of strength in her neck and lower extremity muscles, associated with laughing or excessive situational stress. Over the past few years, they have become concerning to her family and friends, as three episodes of body collapse occurred in public, not associated with loss of consciousness or other trauma.Since her teenage years, she has always felt sleepier than other people, requiring frequent naps during the day, and also describes dreaming during naps. She has been a heavy smoker since early adolescence. After having children, her naps were less frequent while she cared for her 7 children. In her mid-30s, the first “cataplectic” event occurred and was temporally associated with smoking cessation. After this event, the patient chose to resume smoking about 20 cigarettes per day until her mid-70s when she quit cigarette smoking after being diagnosed with coronary heart disease. At that point, a formal sleep evaluation revealed a history of intermittent sleep paralysis and hypnagogic hallucinations.The sleep study was conducted in 1995 and contained 7.5 h of sleep with a 4-min sleep onset REM period. An MSLT performed the next day found a mean sleep latency of 3 min, with REM sleep occurring in 4 of 4 naps. Of note, REM sleep occurred in the first epoch of sleep on all naps. HLA typing for narcolepsy found the patient positive for HLA-DQB1-0602 and HLA-DR15.The patient was offered stimulants at that point; however, she declined them due to concerns regarding potential addiction and rebound effects. Since then, she has opted to use a nicotine patch, which has been effective in controlling her cataplexy. However, over the past 5 years, 3 episodes of cataplexy were noted, most commonly triggered by either surprise or public speaking (e.g., last event occurred when her name was announced for an award at a large conference). On multiple occasions the patient has declined the offer to change to a more standard pharmacotherapy for narcolepsy. Currently, she sleeps for 7-9 h nightly on a regular schedule and naps for 20-30 min, 5-7 times a week. Her family history reveals a mother with very similar symptoms who was told she had narcolepsy in the 1940s. Her mother's condition was well managed on amphetamines until she passed away at the age of 83, in 1982. This familial linkage further strengthens the diagnosis of narcolepsy.12DISCUSSIONIn this case, it appears that both smoking and the use of a nicotine patch may have partially masked both cataplexy and sleepiness. Therefore, once smoking was discontinued, the patient exhibited both increased sleepiness and cataplexy. The fact that nicotine masked sleepiness is not surprising, given that nicotine has been shown to improve memory and attention in humans and animals, similar to amphetamines.13The finding in our case is consistent with Bagai and Malow's finding that a nicotine patch helped treat morning sleepiness in a narcoleptic patient without cataplexy.2 Moreover, in a 2009 survey of narcoleptics by Krahn et al.,1 it was found that all narcoleptics who had smoked in the past reported reduced daytime sleepiness while smoking, and one survey participant reported reduced cataplexy while smoking. Interestingly, passive smoking was found to be more common in narcoleptics, but active smoking was not increased compared to normal controls.14 Our findings, as well as previous reports suggest that smoking and nicotine patches decrease the clinical manifestations of narcolepsy, with reduced cataplexy and daytime sleepiness. Based on these findings, we believe further investigation is warranted to look at the role of nicotine in treatment of both cataplexy and excessive daytime sleepiness in narcoleptics.DISCLOSURE STATEMENTThis was not an industry supported study. The authors have indicated no financial conflicts of interest.REFERENCES1 Krahn LEMartin KASilber MHNarcoleptic patients' perceptions of nicotineJ Clin Sleep Med20095390, 19968021LinkGoogle Scholar2 Bagai KMalow BAA novel approach to treating morning sleep inertia in narcolepsyJ Clin Sleep Med20106778, 20191943LinkGoogle Scholar3 Boissard RGervasoni DSchmidt MHBarbagli BFort PLuppi PHThe rat ponto-medullary network responsible for paradoxical sleep onset and maintenance: a combined microinjection and functional neuroanatomical studyEur J Neurosci200216195973, 12453060CrossrefGoogle Scholar4 Morales FREngelhardt JKSoja PJPereda AEChase MHMotoneuron properties during motor inhibition produced by microinjection of carbachol into the pontine reticular formation of the decerebrate catJ Neurophysiol198757111829, 3585456CrossrefGoogle Scholar5 Domino EFYamamoto KDren ATRole of cholinergic mechanisms in states of wakefulness and sleepProg Brain Res19682811333, 5749010CrossrefGoogle Scholar6 Velazquez-Moctezuma JGillin JCShiromani PJEffect of specific M1, M2 muscarinic receptor agonists on REM sleep generationBrain Res198950312831, 2482113CrossrefGoogle Scholar7 Nissen CNofzinger EAFeige B, et al.Differential effects of the muscarinic M1 receptor agonist RS-86 and the acetylcholine-esterase inhibitor donepezil on REM sleep regulation in healthy volunteersNeuropsychopharmacology2006311294300, 16192980CrossrefGoogle Scholar8 Jaehne ALoessl BBarkai ZRiemann DHornyak MEffects of nicotine on sleep during consumption, withdrawal and replacement therapySleep Med Rev20091336377, 19345124CrossrefGoogle Scholar9 Davila DGHurt RDOfford KPHarris CDShepard JWAcute effects of transdermal nicotine on sleep architecture, snoring, and sleep-disordered breathing in nonsmokersAm J Respir Crit Care Med199415046974, 8049831CrossrefGoogle Scholar10 Gillin JCLardon MRuiz CGolshan SSalin-Pascual RDose-dependent effects of transdermal nicotine on early morning awakening and rapid eye movement sleep time in nonsmoking normal volunteersJ Clin Psychopharmacol1994142647, 7962682CrossrefGoogle Scholar11 Salin-Pascual RJMoro-Lopez MLGonzalez-Sanchez HBlanco-Centurion CChanges in sleep after acute and repeated administration of nicotine in the ratPsychopharmacology (Berl)19991451338, 10463313CrossrefGoogle Scholar12 Chen LFong SYLam CW, et al.The familial risk and HLA susceptibility among narcolepsy patients in Hong Kong ChineseSleep2007308518, 17682655CrossrefGoogle Scholar13 Levin EDMcClernon FJRezvani AHNicotinic effects on cognitive function: behavioral characterization, pharmacological specification, and anatomic localizationPsychopharmacology (Berl)200618452339, 16220335CrossrefGoogle Scholar14 Ton TGLongstreth WTKoepsell TActive and passive smoking and risk of narcolepsy in people with HLA DQB1*0602: a population-based case-control studyNeuroepidemiology20093211421, 19039244CrossrefGoogle Scholar Previous article Next article FiguresReferencesRelatedDetailsCited by Narcolepsy, co-morbidities and smokingDhillon N, Riha R and Dhillon B Sleep Medicine, 10.1016/j.sleep.2018.08.012, Vol. 52, , (236), Online publication date: 1-Dec-2018. Smoking Prevalence and Its Clinical Correlations in Patients with Narcolepsy-cataplexyPeřinová P, Feketeová E, Kemlink D, Kovalská P, Chlebušová K, Nepožitek J, Ibarburu V, Králíková E, Nevšímalová S and Šonka K Prague Medical Report, 10.14712/23362936.2016.8, Vol. 117, No. 2-3, (81-89), . Clinical and practical considerations in the pharmacologic management of narcolepsyThorpy M and Dauvilliers Y Sleep Medicine, 10.1016/j.sleep.2014.10.002, Vol. 16, No. 1, (9-18), Online publication date: 1-Jan-2015. NarkolepsieNarcolepsyMayer G Der Nervenarzt, 10.1007/s00115-013-3889-2, Vol. 85, No. 1, (26-34), Online publication date: 1-Jan-2014. Treatment options in narcolepsyMayer G, Bassetti C and Dauvilliers Y Expert Opinion on Orphan Drugs, 10.1517/21678707.2013.854701, Vol. 1, No. 12, (987-999), Online publication date: 1-Dec-2013. Volume 08 • Issue 02 • April 15, 2012ISSN (print): 1550-9389ISSN (online): 1550-9397Frequency: Monthly Metrics History Submitted for publicationJune 1, 2011Submitted in final revised formOctober 1, 2011Accepted for publicationNovember 1, 2011Published onlineApril 15, 2012 Information© 2012 American Academy of Sleep MedicineKeywordsNarcolepsymaskednicotinesleepinesscataplexyPDF download" @default.
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