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- W2057788850 abstract "Abstract The spleens of young pigs were selectively labeled with tritiated thymidine ([ 3 H]-TdR) and the relative and absolute numbers of labeled lymphocytes found 24 hr later in different lymphoid and nonlymphoid organs were determined autoradiographically. It was deduced that about 4.6 × 10 9 lymphocytes (that is, about 15% of all splenic lymphocytes) are produced by the spleen per day and about 17% of the newly formed lymphocytes leave the spleen within the first day of labeling. Spleen-derived lymphocytes could be found in relatively high numbers in the lymph nodes, blood, gut-associated lymphoid tissues, and, surprisingly, in the bone marrow, whereas the concentration in the thymus was very low. In a second series, pigs were labeled with [ 3 H]TdR and only the spleen was excluded from labeling. The labeling index of splenic small lymphocytes was about 10% 1 day later, indicating a high rate of influx of newly formed lymphocytes into the pig spleen. The spleen of the young pig is an important lymphocytopoietic organ and exports and imports newly formed lymphocytes at high rates." @default.
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- W2057788850 date "1977-09-01" @default.
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- W2057788850 title "Splenic lymphocytopoiesis and migration pattern of splenic lymphocytes" @default.
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- W2057788850 doi "https://doi.org/10.1016/0008-8749(77)90132-0" @default.
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