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- W2057802145 abstract "Graft coronary artery disease (GCAD) is angiographically detected in 20% of heart transplants at 1 year and in nearly 50% at 3 years.1,2 Patients with GCAD affecting 3 vessels have only a 13% 2-year survival compared with 36% for patients with 1-vessel disease.3 GCAD may present as silent myocardial infarction, congestive heart failure, ventricular arrhythmias or sudden death, whereas angina pectoris is uncommon. GCAD is characterized by proliferation of myofibroblasts and deposition of extracellular matrix proteins in the vascular intima in response to either previous tissue damage,4 chronic intermittent lymphatic disruption because of chronic interstitial inflammation5 or replicative senescence of endothelial cells.6" @default.
- W2057802145 created "2016-06-24" @default.
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- W2057802145 date "2000-05-01" @default.
- W2057802145 modified "2023-09-24" @default.
- W2057802145 title "Calcium channel blockers and angiotensin-converting enzyme inhibitors in the prevention of graft vasculopathy" @default.
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- W2057802145 doi "https://doi.org/10.1016/s1053-2498(00)00072-3" @default.
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