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- W2057805061 abstract "Heparin has been said to improve microvascular perfusion in the burn wound. Using 75°C, 10 s, 5 per cent body surface area guinea-pig scald burns, histology was studied and the amount of dermal perfusion was measured periodically after burning. Microcirculatory dermal perfusion was evaluated after indian ink injection. Untreated control animals were compared with animals treated with topical heparin, animals treated with systemic heparin and animals treated with both topical and systemic heparin. Immediately and up to 2 h post burn there was vascular filling to 85 percent thickness of the dermis in all animals. By 8 h, the dermal perfusion had fallen to 40 per cent dermal thickness and at 24 h no dermal perfusion occurred. At 24 h only the subdermal vessels contained indian ink. The animals' wounds which were allowed to heal showed no regeneration of dermal appendages, grossly or microscopically. In this model, heparin failed to prevent progressive dermal ischaemia or to allow regeneration of dermal appendages." @default.
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- W2057805061 date "1979-03-01" @default.
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- W2057805061 title "The effect of heparin on dermal ischaemia after burning" @default.
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- W2057805061 doi "https://doi.org/10.1016/0305-4179(79)90077-9" @default.
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