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- W2057806637 abstract "In autoimmune diseases of the central nervous system (CNS), innate glial cell responses play a key role in determining the outcome of leukocyte infiltration. Access of leukocytes is controlled via complex interactions with glial components of the blood-brain barrier that include angiotensin II receptors on astrocytes and immunoregulatory mediators such as Type I interferons which regulate cellular traffic. Myeloid cells at the blood-brain barrier present antigen to T cells and influence cytokine effector function. Myelin-specific T cells interact with microglia and promote differentiation of oligodendrocyte precursor cells in response to axonal injury. These innate responses offer potential targets for immunomodulatory therapy." @default.
- W2057806637 created "2016-06-24" @default.
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- W2057806637 date "2011-05-27" @default.
- W2057806637 modified "2023-09-26" @default.
- W2057806637 title "Innate immune responses in central nervous system inflammation" @default.
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- W2057806637 doi "https://doi.org/10.1016/j.febslet.2011.05.030" @default.
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