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• W2057807111 abstract "Abstract Axonal injury is a major hallmark of traumatic brain injury (TBI), and it seems likely that therapies directed toward enhancing axon repair could potentially improve functional outcomes. One potential target is chondroitin sulfate proteoglycans (CSPGs), which are major axon growth inhibitory molecules that are generally, but not always, up‐regulated after central nervous system injury. The current study was designed to determine temporal changes in cerebral cortical mRNA or protein expression levels of CSPGs and to determine their regional localization and cellular association by using immunohistochemistry in a controlled cortical impact model of TBI. The results showed significant increases in versican mRNA at 4 and 14 days after TBI but no change in neurocan, aggrecan, or phosphacan. Semiquantitative Western blot (WB) analysis of cortical CSPG protein expression revealed a significant ipsilateral decrease of all CSPGs at 1 day after TBI. Lower CSPG protein levels were sustained until at least 14 days, after which the levels began to normalize. Immunohistochemistry data confirm previous reports of regional increases in CSPG proteins after CNS injury, seen primarily within the developing glial scar after TBI, but also corroborate the WB data by revealing wide areas of pericontusional tissue that are deficient in both extracellular and perineuronal net‐associated CSPGs. Given the evidence that CSPGs are largely inhibitory to axonal growth, we interpret these data to indicate a potential for regional spontaneous plasticity after TBI. If this were the case, the gradual normalization of CSPG proteins over time postinjury would suggest that this may be temporally as well as regionally limited. © 2009 Wiley‐Liss, Inc." @default.
• W2057807111 created "2016-06-24" @default.
• W2057807111 creator A5036547162 @default.
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• W2057807111 date "2009-05-12" @default.
• W2057807111 modified "2023-10-17" @default.
• W2057807111 title "Traumatic brain injury results in disparate regions of chondroitin sulfate proteoglycan expression that are temporally limited" @default.
• W2057807111 cites W1563350378 @default.
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• W2057807111 cites W1672576559 @default.
• W2057807111 cites W1718462190 @default.
• W2057807111 cites W1723871640 @default.
• W2057807111 cites W1760881456 @default.
• W2057807111 cites W1859477582 @default.
• W2057807111 cites W1872912914 @default.
• W2057807111 cites W1897654429 @default.
• W2057807111 cites W1970107990 @default.
• W2057807111 cites W1971469691 @default.
• W2057807111 cites W1976484413 @default.
• W2057807111 cites W1976563891 @default.
• W2057807111 cites W1978031202 @default.
• W2057807111 cites W1978298085 @default.
• W2057807111 cites W1978585388 @default.
• W2057807111 cites W1983280567 @default.
• W2057807111 cites W1990655121 @default.
• W2057807111 cites W1990808942 @default.
• W2057807111 cites W1992278345 @default.
• W2057807111 cites W1996687999 @default.
• W2057807111 cites W1997322142 @default.
• W2057807111 cites W1997912239 @default.
• W2057807111 cites W1998880226 @default.
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• W2057807111 cites W2005416260 @default.
• W2057807111 cites W2009873959 @default.
• W2057807111 cites W2012928251 @default.
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• W2057807111 cites W2017735621 @default.
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• W2057807111 cites W2034369410 @default.
• W2057807111 cites W2050989030 @default.
• W2057807111 cites W2053200671 @default.
• W2057807111 cites W2054063780 @default.
• W2057807111 cites W2056466097 @default.
• W2057807111 cites W2064758161 @default.
• W2057807111 cites W2066556226 @default.
• W2057807111 cites W2067629356 @default.
• W2057807111 cites W2072846301 @default.
• W2057807111 cites W2074745891 @default.
• W2057807111 cites W2075145729 @default.
• W2057807111 cites W2076540617 @default.
• W2057807111 cites W2077850837 @default.
• W2057807111 cites W2084275244 @default.
• W2057807111 cites W2085689721 @default.
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• W2057807111 cites W2097325660 @default.
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• W2057807111 cites W2104968232 @default.
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• W2057807111 cites W2136255872 @default.
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• W2057807111 doi "https://doi.org/10.1002/jnr.22115" @default.
• W2057807111 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2821049" @default.
• W2057807111 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19437549" @default.
• W2057807111 hasPublicationYear "2009" @default.
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