FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2057808857> ?p ?o ?g. }

• W2057808857 endingPage "2463" @default.
• W2057808857 startingPage "2456" @default.
• W2057808857 abstract "Chronic metabolic acidosis results in metabolic bone disease, calcium nephrolithiasis, and growth retardation. The pathogenesis of each of these sequelae is poorly understood in humans. We therefore investigated the effects of chronic extrarenal metabolic acidosis on the regulation of 1,25-(OH)2D, parathyroid hormone, calcium, and phosphate metabolism in normal humans. Chronic extrarenal metabolic acidosis was induced by administering two different doses of NH4Cl [2.1 (low dose) and 4.2 (high dose) mmol/kg body wt per d, respectively] to four male volunteers each during metabolic balance conditions. Plasma [HCO3-] decreased by 4.5 +/- 0.4 mmol/liter in the low dose and by 9.1 +/- 0.3 mmol/liter (P < 0.001) in the high dose group. Metabolic acidosis induced renal hypophosphatemia, which strongly correlated with the severity of acidosis (Plasma [PO4] on plasma [HCO3-]; r = 0.721, P < 0.001). Both metabolic clearance and production rates of 1,25-(OH)2D increased in both groups. In the high dose group, the percentage increase in production rate was much greater than the percentage increase in metabolic clearance rate, resulting in a significantly increased serum 1,25-(OH)2D concentration. A strong inverse correlation was observed for serum 1,25-(OH)2D concentration on both plasma [PO4] (r = -0.711, P < 0.001) and plasma [HCO3-] (r = -0.725, P < 0.001). Plasma ionized calcium concentration did not change in either group whereas intact serum parathyroid hormone concentration decreased significantly in the high dose group. In conclusion, metabolic acidosis results in graded increases in serum 1,25-(OH)2D concentration by stimulating its production rate in humans. The increased production rate is explained by acidosis-induced hypophosphatemia/cellular phosphate depletion resulting at least in part from decreased renal tubular phosphate reabsorption. The decreased serum intact parathyroid hormone levels in more severe acidosis may be the consequence of hypophosphatemia and/or increased serum 1,25-(OH)2D concentrations." @default.
• W2057808857 created "2016-06-24" @default.
• W2057808857 creator A5005685176 @default.
• W2057808857 creator A5006060423 @default.
• W2057808857 creator A5043944479 @default.
• W2057808857 creator A5071429778 @default.
• W2057808857 date "1992-12-01" @default.
• W2057808857 modified "2023-10-13" @default.
• W2057808857 title "Chronic metabolic acidosis increases the serum concentration of 1,25-dihydroxyvitamin D in humans by stimulating its production rate. Critical role of acidosis-induced renal hypophosphatemia." @default.
• W2057808857 cites W1500298901 @default.
• W2057808857 cites W1556156434 @default.
• W2057808857 cites W1805084076 @default.
• W2057808857 cites W181254233 @default.
• W2057808857 cites W1843675084 @default.
• W2057808857 cites W1853647023 @default.
• W2057808857 cites W1969429995 @default.
• W2057808857 cites W1969501963 @default.
• W2057808857 cites W1971726121 @default.
• W2057808857 cites W1972376675 @default.
• W2057808857 cites W1973693285 @default.
• W2057808857 cites W1985774267 @default.
• W2057808857 cites W1988269188 @default.
• W2057808857 cites W1992676730 @default.
• W2057808857 cites W1993455167 @default.
• W2057808857 cites W2009096088 @default.
• W2057808857 cites W2010267091 @default.
• W2057808857 cites W2011321687 @default.
• W2057808857 cites W2011788787 @default.
• W2057808857 cites W2017469258 @default.
• W2057808857 cites W2017758987 @default.
• W2057808857 cites W2031845752 @default.
• W2057808857 cites W2032252282 @default.
• W2057808857 cites W2048164032 @default.
• W2057808857 cites W2050780714 @default.
• W2057808857 cites W2052666573 @default.
• W2057808857 cites W2056077455 @default.
• W2057808857 cites W2059038646 @default.
• W2057808857 cites W2073932205 @default.
• W2057808857 cites W2078582195 @default.
• W2057808857 cites W2079726951 @default.
• W2057808857 cites W2079841815 @default.
• W2057808857 cites W2081548713 @default.
• W2057808857 cites W2084408402 @default.
• W2057808857 cites W2122595857 @default.
• W2057808857 cites W2122857050 @default.
• W2057808857 cites W2123953899 @default.
• W2057808857 cites W2129671445 @default.
• W2057808857 cites W2134792323 @default.
• W2057808857 cites W2142341955 @default.
• W2057808857 cites W2152264881 @default.
• W2057808857 cites W2156887647 @default.
• W2057808857 cites W2164490070 @default.
• W2057808857 cites W2168785688 @default.
• W2057808857 cites W2170831281 @default.
• W2057808857 cites W2234931454 @default.
• W2057808857 cites W2261276457 @default.
• W2057808857 cites W2339872073 @default.
• W2057808857 cites W2341204174 @default.
• W2057808857 cites W2343270216 @default.
• W2057808857 cites W2405374645 @default.
• W2057808857 cites W2409219857 @default.
• W2057808857 cites W2410755427 @default.
• W2057808857 cites W2413052511 @default.
• W2057808857 cites W2414281950 @default.
• W2057808857 cites W1937731143 @default.
• W2057808857 doi "https://doi.org/10.1172/jci116137" @default.
• W2057808857 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/443402" @default.
• W2057808857 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1469097" @default.
• W2057808857 hasPublicationYear "1992" @default.
• W2057808857 type Work @default.
• W2057808857 sameAs 2057808857 @default.
• W2057808857 citedByCount "90" @default.
• W2057808857 countsByYear W20578088572012 @default.
• W2057808857 countsByYear W20578088572013 @default.
• W2057808857 countsByYear W20578088572014 @default.
• W2057808857 countsByYear W20578088572015 @default.
• W2057808857 countsByYear W20578088572016 @default.
• W2057808857 countsByYear W20578088572017 @default.
• W2057808857 countsByYear W20578088572018 @default.
• W2057808857 countsByYear W20578088572019 @default.
• W2057808857 countsByYear W20578088572020 @default.
• W2057808857 countsByYear W20578088572021 @default.
• W2057808857 countsByYear W20578088572022 @default.
• W2057808857 crossrefType "journal-article" @default.
• W2057808857 hasAuthorship W2057808857A5005685176 @default.
• W2057808857 hasAuthorship W2057808857A5006060423 @default.
• W2057808857 hasAuthorship W2057808857A5043944479 @default.
• W2057808857 hasAuthorship W2057808857A5071429778 @default.
• W2057808857 hasBestOaLocation W20578088571 @default.
• W2057808857 hasConcept C126322002 @default.
• W2057808857 hasConcept C134018914 @default.
• W2057808857 hasConcept C176674119 @default.
• W2057808857 hasConcept C185592680 @default.
• W2057808857 hasConcept C2777735490 @default.
• W2057808857 hasConcept C2778553927 @default.
• W2057808857 hasConcept C2778573388 @default.
• W2057808857 hasConcept C2779246250 @default.
• W2057808857 hasConcept C2781208988 @default.

• next