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- W2057819519 abstract "By affinity chromatography utilizing α-cobrotoxin from digitonin-solubilized fractions of rabbit skeletal muscle, we found that many proteins are associated with the nicotinic acetylcholine receptor (AChR). In addition to the proteins we previously reported to bind to AChR (including dystrophin-dystrophin-associated protein (DAP) complex, utrophin, rapsyn, and actin; Mitsui et al. [1996] Biochem. Biophys. Res. Commun.224:802–807), α-actinin, desmin, myosin, tropomyosin, troponin T, and titin are also identified to be associated with AChR. Alkaline treatment or Triton X-100 solubilization released dystrophin-DAP complex, utrophin, and rapsyn from the AChR fraction, while actin and desmin remained associated. These findings demonstrate that AChR is supported primarily by a submembranous organization of actin and desmin filaments, and is linked to sarcomeric proteins via these filaments. To further investigate whether the association has any functional role, we studied the effect of acetylcoline on ATPase activity of the AChR fraction. Acetylcholine (0.5–4 μM) significantly activated Mg2+-ATPase activity of digitonin-solubilized AChR fraction (P < 0.05). Furthermore, we found that desmin as well as actin activated myosin Mg2+-ATPase activity. From these findings, it is suggested that desmin and actin form a submembranous organization in the postsynaptic region, and function as mediators of excitation of AChR to the sarcomeric contraction system. J. Cell. Biochem. 77:584–595, 2000. © 2000 Wiley-Liss, Inc." @default.
- W2057819519 created "2016-06-24" @default.
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- W2057819519 date "2000-06-15" @default.
- W2057819519 modified "2023-10-11" @default.
- W2057819519 title "Functional association between nicotinic acetylcholine receptor and sarcomeric proteins via actin and desmin filaments" @default.
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- W2057819519 doi "https://doi.org/10.1002/(sici)1097-4644(20000615)77:4<584::aid-jcb6>3.0.co;2-u" @default.
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