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• W2057821330 startingPage "31" @default.
• W2057821330 abstract "The present study was designed to assess the effects of adenosine triphosphate (ATP) on hippocampal neurotransmissions under the normal and hypoxic/hypoglycemic conditions. ATP reversely depressed population spikes (PSs), which were monitored in the dentate gyrus of guinea pig hippocampal slices, in a dose-dependent manner at concentrations ranged from 0.1 μM to 1 mM. A similar depression was obtained with the P2 receptor agonist, α,β-methylene ATP (α,β-MeATP), and the effect was inhibited by the P2 receptor antagonists, suramin and PPADS. The inhibitory action of ATP or α,β-MeATP was inhibited by the γ-aminobutyric acidA (GABAA) receptor antagonist, bicuculline, but it was not affected by theophylline, a broad inhibitor of adenosine (P1) receptors, tetraethylammonium, a broad inhibitor of K+ channels, or ecto-protein kinase inhibitors. ATP or α,β-MeATP enhanced GABA release from guinea pig hippocampal slices, that was inhibited by deleting extracellular Ca2+ or in the presence of tetrodotoxin, while ATP had no effect on GABA release from cultured rat hippocampal astrocytes or postsynaptic GABA-gated channel currents in cultured rat hippocampal neurons. Twenty-minutes deprivation of glucose and oxygen from extracellular solution abolished PSs, the amplitude recovering to about 30% of basal levels 50 min after returning to normal conditions. ATP or α,β-MeATP accelerated the recovery after hypoxic/hypoglycemic insult (approximately 80% of basal levels). Adenosine diphosphate and adenosine monophosphate accelerated the recovery, but to a much lesser extent, and adenosine had no effect. The results of the present study thus suggest that ATP inhibits neuronal activity by enhancing neuronal GABA release via a P2 receptor, perhaps a P2X receptor, thereby protecting against hypoxic/hypoglycemic perturbation of hippocampal neurotransmission." @default.
• W2057821330 created "2016-06-24" @default.
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• W2057821330 date "2002-10-01" @default.
• W2057821330 modified "2023-10-13" @default.
• W2057821330 title "Adenosine triphosphate accelerates recovery from hypoxic/hypoglycemic perturbation of guinea pig hippocampal neurotransmission via a P2 receptor" @default.
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• W2057821330 doi "https://doi.org/10.1016/s0006-8993(02)03185-2" @default.
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