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- W2057842018 abstract "Recombinant adeno-associated virus (rAAV) vectors are based on a non-pathogenic human parvovirus (AAV) that is unique in its ability to persist in human cells without causing any pathologic effects. Studies of the potential barriers to rAAV-mediated transduction of relatively resistant cells has led to an understanding of the mechanisms of cell attachment and entry, cytoplasmic translocation, nuclear entry, conversion to active double-stranded DNA, activation of transcription and establishment of persistent molecular forms. Each of these areas is individually discussed, as are recent applications in vivo in preclinical models and clinical trials." @default.
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- W2057842018 date "2004-07-01" @default.
- W2057842018 modified "2023-10-16" @default.
- W2057842018 title "Recombinant adeno-associated virus vectors for gene therapy" @default.
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- W2057842018 doi "https://doi.org/10.1517/14712598.4.7.1093" @default.
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