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• W2057847218 abstract "Rabbits, guinea pigs, rats and mice were compared for the activity of benzo[a]pyrene hydroxylase. aminopyrine N-demethylase and aniline hydroxylase of pulmonary microsomes. The activity of the microsomal enzymes was highest in rabbits, followed by guinea pigs and then rats and mice. Effects of the inhalation of cadmium oxides (CdO) were studied on the pulmonary microsomal enzymes in male rabbits. Rabbits were exposed for 15 min to air containing microparticles of CdO at four different concentrations ranging from 6.4 ± 0.5 to 22.4 ± 0.4 mg Cd/m3. The animals were killed 24 hr after the inhalation of CdO. The lung weight of the animals was increased markedly at doses higher than 12.6 mg/m3, the increase attaining 50 per cent increase at the highest dose. The activity of benzo[a]pyrene hydroxylase was reduced significantly at the higher doses, the reduction being dose-dependent reaching 50 per cent reduction. The activity of aminopyrine N-demethylase and aniline hydroxylase was reduced moderately by CdO inhalation but the reduction was not dose-dependent. Time-course effects of CdO inhalation on the pulmonary microsomal enzymes were studied on the rabbits exposed for 15 min to air containing CdO at concentrations of 13.0 ± 0.3 mg Cd/m3. The animals were killed 0.5, 1, 2, 4, and 6 days after the inhalation. The body weight increase was less in the treated groups than in the controls and edematous lesions in the lung were observed in most of the treated animals. The lung weight was increased after the inhalation, reaching its plateau on day 4. The activity of the microsomal enzymes was reduced throughout the experimental period, the maximum reduction being obtained on day 2 after the inhalation except for aniline hydroxylase that was reduced at the same degree throughout the experimental period." @default.
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• W2057847218 date "1981-04-01" @default.
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• W2057847218 title "Effects of short-term inhalation of cadmium oxides on rabbit pulmonary microsomal enzymes" @default.
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• W2057847218 doi "https://doi.org/10.1016/0006-2952(81)90156-8" @default.
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