Matches in SemOpenAlex for { <https://semopenalex.org/work/W2057851034> ?p ?o ?g. }
Showing items 1 to 93 of
93
with 100 items per page.
- W2057851034 endingPage "690" @default.
- W2057851034 startingPage "683" @default.
- W2057851034 abstract "1. A significant renal vasodilation was observed previously after an acute cyclo-oxygenase (COX) inhibition induced with indomethacin. Because this effect could be due to COX-dependent intrarenal metabolization of arachidonic acid through cytochrome P450 (CYP450) pathways, the aim of the present study was to investigate, in vivo, possible interactions between COX and CYP450 mono-oxygenases. 2. Mean arterial pressure (MAP) and renal blood flow (RBF), using an electromagnetic flow transducer for RBF evaluation, were measured continuously in 71 anaesthetized euvolaemic rats. Appropriate solvents (vehicle), 3 mg/kg indomethacin, 17-octadecynoic acid (17-ODYA; 2 mmol/L), either miconazole (MI; 1.5 mmol/L) or N-methylsulphonyl-6-(2-propargyloxyphenyl)hexanamide (MS-PPOH; 5 mg/kg) and N′-hydroxyphenylformamidine (HET0016; 5 or 10 mg/kg) were administered to inhibit either COX, CYP450 mono-oxygenases, epoxygenases or hydroxylase, respectively. The CYP450 and COX inhibitors were also combined as follows: 17-ODYA/indomethacin, MI (or MS-PPOH)/indomethacin, HET0016/indomethacin and indomethacin/HET0016. 3. Mean arterial pressure and RBF were not modified by vehicle, 17-ODYA or MI (or MS-PPOH). However, MAP decreased slightly (P < 0.05; paired t-test, 5 d.f.) and RBF increased transiently (P < 0.05; anova, 5 d.f.) after HET0016. In contrast, MAP decreased by 10 mmHg (P < 0.05) and RBF increased by 10% (P < 0.05) after indomethacin. This enhancement was prevented by 17-ODYA or MI (or MS-PPOH), but not by HET0016. Moreover, RBF increased step-wise to 21% in the indomethacin/HET0016 experiment (P < 0.05). Consequently, changes from baseline in renal vascular resistance differed among treatments, averaging −2 ± 3 (vehicle), −13 ± 3 (indomethacin; P < 0.05 vs vehicle), −4 ± 3 (17-ODYA/indomethacin), −3 ± 4 (MI or MS-PPOH/indomethacin), −15 ± 3 (HET0016/indomethacin; P < 0.05) and −22 ± 4% (indomethacin/HET0016; P < 0.05). 4. In conclusion, these results demonstrate that the renal vasodilation induced by indomethacin can be prevented by prior inhibition of CYP450 mono-oxygenases and further suggest that the CYP450 epoxygenases pathway may prevail." @default.
- W2057851034 created "2016-06-24" @default.
- W2057851034 creator A5033726943 @default.
- W2057851034 creator A5057265462 @default.
- W2057851034 creator A5058581693 @default.
- W2057851034 creator A5077198825 @default.
- W2057851034 creator A5084021789 @default.
- W2057851034 creator A5091651705 @default.
- W2057851034 date "2004-10-01" @default.
- W2057851034 modified "2023-09-26" @default.
- W2057851034 title "Changes in renal haemodynamics induced by indomethacin in the rat involve cytochrome P450 arachidonic acid-dependent epoxygenases" @default.
- W2057851034 cites W189437941 @default.
- W2057851034 cites W1977332195 @default.
- W2057851034 cites W1995142464 @default.
- W2057851034 cites W2010432526 @default.
- W2057851034 cites W2041661025 @default.
- W2057851034 cites W2044127659 @default.
- W2057851034 cites W2046659117 @default.
- W2057851034 cites W2117594247 @default.
- W2057851034 cites W2127430534 @default.
- W2057851034 cites W2140966051 @default.
- W2057851034 cites W2168349092 @default.
- W2057851034 cites W2341461529 @default.
- W2057851034 cites W2411418912 @default.
- W2057851034 cites W2434576299 @default.
- W2057851034 cites W4251209917 @default.
- W2057851034 doi "https://doi.org/10.1111/j.0305-1870.2004.04066.x" @default.
- W2057851034 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15554908" @default.
- W2057851034 hasPublicationYear "2004" @default.
- W2057851034 type Work @default.
- W2057851034 sameAs 2057851034 @default.
- W2057851034 citedByCount "6" @default.
- W2057851034 crossrefType "journal-article" @default.
- W2057851034 hasAuthorship W2057851034A5033726943 @default.
- W2057851034 hasAuthorship W2057851034A5057265462 @default.
- W2057851034 hasAuthorship W2057851034A5058581693 @default.
- W2057851034 hasAuthorship W2057851034A5077198825 @default.
- W2057851034 hasAuthorship W2057851034A5084021789 @default.
- W2057851034 hasAuthorship W2057851034A5091651705 @default.
- W2057851034 hasConcept C120770815 @default.
- W2057851034 hasConcept C126322002 @default.
- W2057851034 hasConcept C134018914 @default.
- W2057851034 hasConcept C178853913 @default.
- W2057851034 hasConcept C181199279 @default.
- W2057851034 hasConcept C185592680 @default.
- W2057851034 hasConcept C2776352881 @default.
- W2057851034 hasConcept C2776452961 @default.
- W2057851034 hasConcept C2777953023 @default.
- W2057851034 hasConcept C2778078955 @default.
- W2057851034 hasConcept C2780091579 @default.
- W2057851034 hasConcept C526171541 @default.
- W2057851034 hasConcept C55493867 @default.
- W2057851034 hasConcept C71924100 @default.
- W2057851034 hasConcept C84393581 @default.
- W2057851034 hasConcept C98274493 @default.
- W2057851034 hasConceptScore W2057851034C120770815 @default.
- W2057851034 hasConceptScore W2057851034C126322002 @default.
- W2057851034 hasConceptScore W2057851034C134018914 @default.
- W2057851034 hasConceptScore W2057851034C178853913 @default.
- W2057851034 hasConceptScore W2057851034C181199279 @default.
- W2057851034 hasConceptScore W2057851034C185592680 @default.
- W2057851034 hasConceptScore W2057851034C2776352881 @default.
- W2057851034 hasConceptScore W2057851034C2776452961 @default.
- W2057851034 hasConceptScore W2057851034C2777953023 @default.
- W2057851034 hasConceptScore W2057851034C2778078955 @default.
- W2057851034 hasConceptScore W2057851034C2780091579 @default.
- W2057851034 hasConceptScore W2057851034C526171541 @default.
- W2057851034 hasConceptScore W2057851034C55493867 @default.
- W2057851034 hasConceptScore W2057851034C71924100 @default.
- W2057851034 hasConceptScore W2057851034C84393581 @default.
- W2057851034 hasConceptScore W2057851034C98274493 @default.
- W2057851034 hasIssue "10" @default.
- W2057851034 hasLocation W20578510341 @default.
- W2057851034 hasLocation W20578510342 @default.
- W2057851034 hasOpenAccess W2057851034 @default.
- W2057851034 hasPrimaryLocation W20578510341 @default.
- W2057851034 hasRelatedWork W1988147934 @default.
- W2057851034 hasRelatedWork W2091622220 @default.
- W2057851034 hasRelatedWork W2116704287 @default.
- W2057851034 hasRelatedWork W2184872970 @default.
- W2057851034 hasRelatedWork W2409118656 @default.
- W2057851034 hasRelatedWork W2441207318 @default.
- W2057851034 hasRelatedWork W2810217845 @default.
- W2057851034 hasRelatedWork W3024045346 @default.
- W2057851034 hasRelatedWork W3090158213 @default.
- W2057851034 hasRelatedWork W3121137001 @default.
- W2057851034 hasVolume "31" @default.
- W2057851034 isParatext "false" @default.
- W2057851034 isRetracted "false" @default.
- W2057851034 magId "2057851034" @default.
- W2057851034 workType "article" @default.