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- W2057859281 abstract "To determine whether long vagal cholinergic pathways are involved in erythromycin-induced pancreatic polypeptide release, erythromycin was administered as an intravenous bolus injection to 9 healthy volunteers (group A) and to 13 patients (group B) with impaired vagal function as a result of truncal vagotomy or accidental vagotomy after antireflux surgery. In 7 of these patients (group Bi) an antrectomy was also performed, while in the other 6 patients (group B2) the antrum was not removed. Pancreatic polypeptide was measured by radioimmunoassay at 5-min intervals twice before and at 2, 5, 10, 15, 30, 45 and 60 min after a 3.5 mg/kg bolus injection of erythromycin. On another day, a standard meal was administered and plasma pancreatic polypeptide was measured at 10-min intervals for 1 h. Erythromycin injection resulted in a lower integrated pancreatic polypeptide response in the patients of group B, (247 ± 89 pmol/l × 15 min; p = 0.005) and group B2 (497 ± 111 pmol/l × 15 min; p = 0.05) when compared to the healthy subjects of group A (1,136 ± 227pmol/l × 15 min). The pancreatic polypeptide response to erythromycin in group B1 was reduced when compared to group B2, but the difference just failed to reach statistical significance (0.05 < p < 0.10). In the first 30 min after ingestion of a meal (cephalic phase) pancreatic polypeptide release was also markedly lower in group B1 (1,461 ± 304 pmol/l × 30 min; p < 0.005) and group B2 (1,452 ± 215 pmol/l × 30 min; p < 0.005) when compared to group A (3,541 ± 452 pmol/l × 30 min). However, in the second 30 min after ingestion of a meal (intestinal phase), no significant difference in pancreatic polypeptide response was observed between group A, B1 and group B2 (3,689 ± 690pmol/l × 30 min, 3,319 ± 938 pmol/l × 30 min and 3,119 ± 761 pmol/l × 30 min, respectively). These last results demonstrate that pancreatic polypeptide cells were functional in all patients and controls. We conclude that the effect of erythromycin on pancreatic polypeptide release is at least in part dependent on intact long vagal cholinergic pathways. Furthermore, preservation of the antrum seems to be of importance for erythromycin-induced pancreatic polypeptide release." @default.
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- W2057859281 date "1994-01-01" @default.
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- W2057859281 title "Effect of Erythromycin on Pancreatic Polypeptide Release: Role of the Vagal Nerve" @default.
- W2057859281 doi "https://doi.org/10.1159/000126780" @default.
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