Matches in SemOpenAlex for { <https://semopenalex.org/work/W2057860166> ?p ?o ?g. }
Showing items 1 to 98 of
98
with 100 items per page.
- W2057860166 endingPage "399" @default.
- W2057860166 startingPage "393" @default.
- W2057860166 abstract "Cortisol and steroids with progestational or androgenic activity were studied to determine the effects of these steroids on the conversion of androstenedione (A) to estrone (E1) in human cultured breast carcinoma cells. Cortisol (10−6M) stimulated aromatase activity in two estrogen unresponsive cell lines (MD, DM) and in an estrogen responsive cell line (MCF7) with the maximum stimulation occurring during confluence. Cortisol inhibited the replication of MCF7 cells but not MD and DM. Dihydrotestosterone, androsterone and 5α-androstanedione (10−6M) inhibited the conversion of A to E1 by greater than 90% under basal and cortisol stimulated conditions. Progesterone (10−6M) had no effect on aromatase activity while the progestational agent R5020 (10−6M) produced a 30% inhibition. The anabolic steroids 19-nortestosterone and 19-norandrostenedione which also have progestational activity inhibited the conversion of A to E1 in a dose dependent manner with 90% inhibition at 10−6M. Danazol (10−6M) a drug with both androgenic and progestational activity inhibited E1 formation by 30%. Under the same conditions, the known inhibitor of aromatase, 4-hydroxyandrostenedione (10−6M) decreased E1 formation by more than 90% and aminoglutethimide (10−6M) caused only 25% inhibition. These studies demonstrate that endogenous and exogenous steroids may have significant effects in modulating the local formation of estrogens from androgen precursors in cultured breast carcinoma cells. This effect on estrogen formation may be a factor in the biological response of breast tissue." @default.
- W2057860166 created "2016-06-24" @default.
- W2057860166 creator A5013594080 @default.
- W2057860166 creator A5041084750 @default.
- W2057860166 creator A5068731583 @default.
- W2057860166 creator A5070689708 @default.
- W2057860166 creator A5085367117 @default.
- W2057860166 date "1988-04-01" @default.
- W2057860166 modified "2023-10-11" @default.
- W2057860166 title "Steroid modulation of aromatase activity in human cultured breast carcinoma cells" @default.
- W2057860166 cites W1601438131 @default.
- W2057860166 cites W1977341404 @default.
- W2057860166 cites W1991322100 @default.
- W2057860166 cites W1994587492 @default.
- W2057860166 cites W2009231034 @default.
- W2057860166 cites W2012059718 @default.
- W2057860166 cites W2039255529 @default.
- W2057860166 cites W2041249608 @default.
- W2057860166 cites W2071847316 @default.
- W2057860166 cites W2086331553 @default.
- W2057860166 cites W2090893404 @default.
- W2057860166 cites W2103230058 @default.
- W2057860166 cites W2148777110 @default.
- W2057860166 cites W2154015003 @default.
- W2057860166 cites W2320302422 @default.
- W2057860166 cites W89320396 @default.
- W2057860166 doi "https://doi.org/10.1016/0022-4731(88)90248-8" @default.
- W2057860166 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3374128" @default.
- W2057860166 hasPublicationYear "1988" @default.
- W2057860166 type Work @default.
- W2057860166 sameAs 2057860166 @default.
- W2057860166 citedByCount "62" @default.
- W2057860166 countsByYear W20578601662013 @default.
- W2057860166 countsByYear W20578601662014 @default.
- W2057860166 countsByYear W20578601662015 @default.
- W2057860166 countsByYear W20578601662022 @default.
- W2057860166 crossrefType "journal-article" @default.
- W2057860166 hasAuthorship W2057860166A5013594080 @default.
- W2057860166 hasAuthorship W2057860166A5041084750 @default.
- W2057860166 hasAuthorship W2057860166A5068731583 @default.
- W2057860166 hasAuthorship W2057860166A5070689708 @default.
- W2057860166 hasAuthorship W2057860166A5085367117 @default.
- W2057860166 hasConcept C121608353 @default.
- W2057860166 hasConcept C126322002 @default.
- W2057860166 hasConcept C134018914 @default.
- W2057860166 hasConcept C185592680 @default.
- W2057860166 hasConcept C2776166826 @default.
- W2057860166 hasConcept C2776683971 @default.
- W2057860166 hasConcept C2777164284 @default.
- W2057860166 hasConcept C2777911890 @default.
- W2057860166 hasConcept C2778656385 @default.
- W2057860166 hasConcept C2779279991 @default.
- W2057860166 hasConcept C2779746161 @default.
- W2057860166 hasConcept C2779881493 @default.
- W2057860166 hasConcept C2780902042 @default.
- W2057860166 hasConcept C530470458 @default.
- W2057860166 hasConcept C71315377 @default.
- W2057860166 hasConcept C71924100 @default.
- W2057860166 hasConcept C86803240 @default.
- W2057860166 hasConceptScore W2057860166C121608353 @default.
- W2057860166 hasConceptScore W2057860166C126322002 @default.
- W2057860166 hasConceptScore W2057860166C134018914 @default.
- W2057860166 hasConceptScore W2057860166C185592680 @default.
- W2057860166 hasConceptScore W2057860166C2776166826 @default.
- W2057860166 hasConceptScore W2057860166C2776683971 @default.
- W2057860166 hasConceptScore W2057860166C2777164284 @default.
- W2057860166 hasConceptScore W2057860166C2777911890 @default.
- W2057860166 hasConceptScore W2057860166C2778656385 @default.
- W2057860166 hasConceptScore W2057860166C2779279991 @default.
- W2057860166 hasConceptScore W2057860166C2779746161 @default.
- W2057860166 hasConceptScore W2057860166C2779881493 @default.
- W2057860166 hasConceptScore W2057860166C2780902042 @default.
- W2057860166 hasConceptScore W2057860166C530470458 @default.
- W2057860166 hasConceptScore W2057860166C71315377 @default.
- W2057860166 hasConceptScore W2057860166C71924100 @default.
- W2057860166 hasConceptScore W2057860166C86803240 @default.
- W2057860166 hasIssue "4" @default.
- W2057860166 hasLocation W20578601661 @default.
- W2057860166 hasLocation W20578601662 @default.
- W2057860166 hasOpenAccess W2057860166 @default.
- W2057860166 hasPrimaryLocation W20578601661 @default.
- W2057860166 hasRelatedWork W10584146 @default.
- W2057860166 hasRelatedWork W1933650521 @default.
- W2057860166 hasRelatedWork W1977689885 @default.
- W2057860166 hasRelatedWork W1987557870 @default.
- W2057860166 hasRelatedWork W2006398865 @default.
- W2057860166 hasRelatedWork W2030936036 @default.
- W2057860166 hasRelatedWork W2031520958 @default.
- W2057860166 hasRelatedWork W2035379017 @default.
- W2057860166 hasRelatedWork W2050502170 @default.
- W2057860166 hasRelatedWork W2050514298 @default.
- W2057860166 hasVolume "29" @default.
- W2057860166 isParatext "false" @default.
- W2057860166 isRetracted "false" @default.
- W2057860166 magId "2057860166" @default.
- W2057860166 workType "article" @default.