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• W2057866029 abstract "—We have used a spin-labeled fatty acid to detect changes induced by light and by cGMP in isolated rod outer segment membranes. We chose a spin probe (5-doxylstearic acid) which has the nitroxide group placed on the hydrocarbon chain, so the probe should reside somewhat inside the hydrophobic region of the membrane. We found that light exposures which bleached the rhodopsin also produced a small change in the EPR spectra. The spectral changes are consistent with a small increase in membrane fluidity. Light exposures which bleach rhodopsin are known to activate a phosphodiesterase that markedly decreases the cGMP level in rod outer segment. Therefore, we attempted to vary cGMP levels directly by adding Bu2-cGMP, or indirectly, by adding IBMX, CDTA or ATP to try to inhibit the phosphodiesterase. In each case where the cGMP level is expected to increase, we observed spectral changes in the dark which suggested a small decrease in membrane fluidity. Thus, all of our results with this probe are consistent with the idea that changing the level of cGMP produces changes in membrane fluidity. The light-induced spectral changes we observed required the presence of ATP, and were inhibited by 2mM Ca2+, or by the chelator of divalent cations, CDTA." @default.
• W2057866029 created "2016-06-24" @default.
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• W2057866029 date "1979-04-01" @default.
• W2057866029 modified "2023-09-27" @default.
• W2057866029 title "EFFECTS OF LIGHT AND cGMP ON MEMBRANE FLUIDITY OF FROG ROD OUTER SEGMENTS" @default.
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• W2057866029 doi "https://doi.org/10.1111/j.1751-1097.1979.tb07754.x" @default.
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