FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2057871021> ?p ?o ?g. }

• W2057871021 endingPage "1638" @default.
• W2057871021 startingPage "1635" @default.
• W2057871021 abstract "To study the role of cell-mediated immunity in chronic hepatitis B (cHB) we have cloned T cells from liver biopsies of 14 patients with cHB. As a first step, T cell lines were established from lymphocytes infiltrating the liver by culturing the biopsied specimens with autologous feeder cells and interleukin 2 (IL2). Fifty-eight clones obtained by limiting dilution showed phenotypic stability over periods of 2–26 weeks. Of the 58 clones 50 were of the “cytotoxic/suppressor” T cell subset (CD8) as defined by the monoclonal antibody T811. Only 8 of 58 clones were of the “helper/inducer” phenotype (CD4) as defined by the monoclonal antibody T151. Functional studies on 9 clones (7 of CD8+ phenotype, 2 of CD4+ phenotype) revealed high cytotoxic activity of all of these clones in a lectin-dependent cell-mediated cytotoxicity assay reflecting the killing capacity of cytotoxic T lymphocytes. All 9 clones lacked significant natural killer activity, while two additional CD8+ clones that also expressed the VEP13 antigen showed significant natural killer activity. For none of the clones tested could killer cell activity (ADCC) be demonstrated. The studies demonstrate that the clonal expansion of T lymphocytes from liver biopsies of patients with cHB in the absence of detectable antigen is possible. The propagation of in vivo activated cytolytic T lymphocytes points to an active role of these cells in the pathogenesis of this disease." @default.
• W2057871021 created "2016-06-24" @default.
• W2057871021 creator A5001528551 @default.
• W2057871021 creator A5004014900 @default.
• W2057871021 creator A5014956564 @default.
• W2057871021 creator A5042988536 @default.
• W2057871021 creator A5045008840 @default.
• W2057871021 creator A5050651574 @default.
• W2057871021 creator A5052820298 @default.
• W2057871021 creator A5083074963 @default.
• W2057871021 date "1986-01-01" @default.
• W2057871021 modified "2023-09-24" @default.
• W2057871021 title "Cytolytic T cell clones derived from liver tissue of patients with chronic hepatitis B" @default.
• W2057871021 cites W137344748 @default.
• W2057871021 cites W141989015 @default.
• W2057871021 cites W1862093504 @default.
• W2057871021 cites W1968475749 @default.
• W2057871021 cites W1974287203 @default.
• W2057871021 cites W1982200932 @default.
• W2057871021 cites W2025200502 @default.
• W2057871021 cites W2028926073 @default.
• W2057871021 cites W2047521337 @default.
• W2057871021 cites W2051962533 @default.
• W2057871021 cites W2063136172 @default.
• W2057871021 cites W2075169501 @default.
• W2057871021 cites W2089605716 @default.
• W2057871021 cites W2107359414 @default.
• W2057871021 cites W2165271672 @default.
• W2057871021 cites W2168320467 @default.
• W2057871021 doi "https://doi.org/10.1002/eji.1830161227" @default.
• W2057871021 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3493151" @default.
• W2057871021 hasPublicationYear "1986" @default.
• W2057871021 type Work @default.
• W2057871021 sameAs 2057871021 @default.
• W2057871021 citedByCount "22" @default.
• W2057871021 crossrefType "journal-article" @default.
• W2057871021 hasAuthorship W2057871021A5001528551 @default.
• W2057871021 hasAuthorship W2057871021A5004014900 @default.
• W2057871021 hasAuthorship W2057871021A5014956564 @default.
• W2057871021 hasAuthorship W2057871021A5042988536 @default.
• W2057871021 hasAuthorship W2057871021A5045008840 @default.
• W2057871021 hasAuthorship W2057871021A5050651574 @default.
• W2057871021 hasAuthorship W2057871021A5052820298 @default.
• W2057871021 hasAuthorship W2057871021A5083074963 @default.
• W2057871021 hasConcept C129374314 @default.
• W2057871021 hasConcept C147483822 @default.
• W2057871021 hasConcept C153911025 @default.
• W2057871021 hasConcept C154317977 @default.
• W2057871021 hasConcept C159047783 @default.
• W2057871021 hasConcept C159654299 @default.
• W2057871021 hasConcept C167672396 @default.
• W2057871021 hasConcept C202751555 @default.
• W2057871021 hasConcept C203014093 @default.
• W2057871021 hasConcept C2776090121 @default.
• W2057871021 hasConcept C2778102761 @default.
• W2057871021 hasConcept C2992881475 @default.
• W2057871021 hasConcept C40677261 @default.
• W2057871021 hasConcept C542903549 @default.
• W2057871021 hasConcept C55493867 @default.
• W2057871021 hasConcept C73588182 @default.
• W2057871021 hasConcept C86803240 @default.
• W2057871021 hasConcept C8891405 @default.
• W2057871021 hasConceptScore W2057871021C129374314 @default.
• W2057871021 hasConceptScore W2057871021C147483822 @default.
• W2057871021 hasConceptScore W2057871021C153911025 @default.
• W2057871021 hasConceptScore W2057871021C154317977 @default.
• W2057871021 hasConceptScore W2057871021C159047783 @default.
• W2057871021 hasConceptScore W2057871021C159654299 @default.
• W2057871021 hasConceptScore W2057871021C167672396 @default.
• W2057871021 hasConceptScore W2057871021C202751555 @default.
• W2057871021 hasConceptScore W2057871021C203014093 @default.
• W2057871021 hasConceptScore W2057871021C2776090121 @default.
• W2057871021 hasConceptScore W2057871021C2778102761 @default.
• W2057871021 hasConceptScore W2057871021C2992881475 @default.
• W2057871021 hasConceptScore W2057871021C40677261 @default.
• W2057871021 hasConceptScore W2057871021C542903549 @default.
• W2057871021 hasConceptScore W2057871021C55493867 @default.
• W2057871021 hasConceptScore W2057871021C73588182 @default.
• W2057871021 hasConceptScore W2057871021C86803240 @default.
• W2057871021 hasConceptScore W2057871021C8891405 @default.
• W2057871021 hasIssue "12" @default.
• W2057871021 hasLocation W20578710211 @default.
• W2057871021 hasLocation W20578710212 @default.
• W2057871021 hasOpenAccess W2057871021 @default.
• W2057871021 hasPrimaryLocation W20578710211 @default.
• W2057871021 hasRelatedWork W148140663 @default.
• W2057871021 hasRelatedWork W1941294166 @default.
• W2057871021 hasRelatedWork W1987331268 @default.
• W2057871021 hasRelatedWork W2018916009 @default.
• W2057871021 hasRelatedWork W2027256771 @default.
• W2057871021 hasRelatedWork W2057871021 @default.
• W2057871021 hasRelatedWork W2153742280 @default.
• W2057871021 hasRelatedWork W2161183983 @default.
• W2057871021 hasRelatedWork W2164750677 @default.
• W2057871021 hasRelatedWork W2416645974 @default.
• W2057871021 hasVolume "16" @default.
• W2057871021 isParatext "false" @default.
• W2057871021 isRetracted "false" @default.

• next