Matches in SemOpenAlex for { <https://semopenalex.org/work/W2057872890> ?p ?o ?g. }
- W2057872890 endingPage "110" @default.
- W2057872890 startingPage "99" @default.
- W2057872890 abstract "Skeletal muscle side population (SP) cells are thought to be stem-like cells. Despite reports confirming the ability of muscle SP cells to give rise to differentiated progeny in vitro and in vivo, the molecular mechanisms defining their phenotype remain unclear. In this study, gene expression analyses of human fetal skeletal muscle demonstrate that bone morphogenetic protein 4 (BMP4) is highly expressed in SP cells but not in main population (MP) mononuclear muscle-derived cells. Functional studies revealed that BMP4 specifically induces proliferation of BMP receptor 1a-positive MP cells but has no effect on SP cells, which are BMPR1a-negative. In contrast, the BMP4 antagonist Gremlin, specifically up-regulated in MP cells, counteracts the stimulatory effects of BMP4 and inhibits proliferation of BMPR1a-positive muscle cells. In vivo, BMP4-positive cells can be found in the proximity of BMPR1a-positive cells in the interstitial spaces between myofibers. Gremlin is expressed by mature myofibers and interstitial cells, which are separate from BMP4-expressing cells. Together, these studies propose that BMP4 and Gremlin, which are highly expressed by human fetal skeletal muscle SP and MP cells, respectively, are regulators of myogenic progenitor proliferation." @default.
- W2057872890 created "2016-06-24" @default.
- W2057872890 creator A5018856906 @default.
- W2057872890 creator A5020475908 @default.
- W2057872890 creator A5022291678 @default.
- W2057872890 creator A5031817044 @default.
- W2057872890 creator A5054056109 @default.
- W2057872890 creator A5059492810 @default.
- W2057872890 creator A5062377669 @default.
- W2057872890 creator A5078633121 @default.
- W2057872890 creator A5088509061 @default.
- W2057872890 creator A5089843842 @default.
- W2057872890 date "2006-10-02" @default.
- W2057872890 modified "2023-10-11" @default.
- W2057872890 title "Regulation of myogenic progenitor proliferation in human fetal skeletal muscle by BMP4 and its antagonist Gremlin" @default.
- W2057872890 cites W116758555 @default.
- W2057872890 cites W133253872 @default.
- W2057872890 cites W1483167997 @default.
- W2057872890 cites W1494055834 @default.
- W2057872890 cites W1565817365 @default.
- W2057872890 cites W162490457 @default.
- W2057872890 cites W176189142 @default.
- W2057872890 cites W1794673492 @default.
- W2057872890 cites W1935346479 @default.
- W2057872890 cites W1953391358 @default.
- W2057872890 cites W1966858831 @default.
- W2057872890 cites W1971314280 @default.
- W2057872890 cites W1973546377 @default.
- W2057872890 cites W1973879435 @default.
- W2057872890 cites W1973902475 @default.
- W2057872890 cites W1975025595 @default.
- W2057872890 cites W1978405687 @default.
- W2057872890 cites W1980481067 @default.
- W2057872890 cites W1985772081 @default.
- W2057872890 cites W1991518335 @default.
- W2057872890 cites W1992396018 @default.
- W2057872890 cites W1993932646 @default.
- W2057872890 cites W1995060691 @default.
- W2057872890 cites W1995621893 @default.
- W2057872890 cites W2007375364 @default.
- W2057872890 cites W2012449451 @default.
- W2057872890 cites W2014363686 @default.
- W2057872890 cites W2016965630 @default.
- W2057872890 cites W2026118162 @default.
- W2057872890 cites W2029914169 @default.
- W2057872890 cites W2033771065 @default.
- W2057872890 cites W2041823687 @default.
- W2057872890 cites W2042765466 @default.
- W2057872890 cites W2044384686 @default.
- W2057872890 cites W2050499746 @default.
- W2057872890 cites W2050972354 @default.
- W2057872890 cites W2053009960 @default.
- W2057872890 cites W2056598800 @default.
- W2057872890 cites W2056818201 @default.
- W2057872890 cites W2061434701 @default.
- W2057872890 cites W2080557529 @default.
- W2057872890 cites W2080592158 @default.
- W2057872890 cites W2081544530 @default.
- W2057872890 cites W2084936584 @default.
- W2057872890 cites W2087144973 @default.
- W2057872890 cites W2087803244 @default.
- W2057872890 cites W2089374787 @default.
- W2057872890 cites W2089886323 @default.
- W2057872890 cites W2090334691 @default.
- W2057872890 cites W2092077225 @default.
- W2057872890 cites W2093297920 @default.
- W2057872890 cites W2100250587 @default.
- W2057872890 cites W2105820250 @default.
- W2057872890 cites W2106133121 @default.
- W2057872890 cites W2107353510 @default.
- W2057872890 cites W2112508321 @default.
- W2057872890 cites W2112513572 @default.
- W2057872890 cites W2118942329 @default.
- W2057872890 cites W2122683221 @default.
- W2057872890 cites W2124326407 @default.
- W2057872890 cites W2129364091 @default.
- W2057872890 cites W2129613706 @default.
- W2057872890 cites W2131291167 @default.
- W2057872890 cites W2137956382 @default.
- W2057872890 cites W2161297275 @default.
- W2057872890 cites W2161736514 @default.
- W2057872890 cites W2283717565 @default.
- W2057872890 cites W4251845825 @default.
- W2057872890 cites W64476291 @default.
- W2057872890 doi "https://doi.org/10.1083/jcb.200511036" @default.
- W2057872890 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2064502" @default.
- W2057872890 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17015616" @default.
- W2057872890 hasPublicationYear "2006" @default.
- W2057872890 type Work @default.
- W2057872890 sameAs 2057872890 @default.
- W2057872890 citedByCount "60" @default.
- W2057872890 countsByYear W20578728902012 @default.
- W2057872890 countsByYear W20578728902013 @default.
- W2057872890 countsByYear W20578728902014 @default.
- W2057872890 countsByYear W20578728902016 @default.
- W2057872890 countsByYear W20578728902017 @default.
- W2057872890 countsByYear W20578728902018 @default.
- W2057872890 countsByYear W20578728902019 @default.