Matches in SemOpenAlex for { <https://semopenalex.org/work/W2057873365> ?p ?o ?g. }
- W2057873365 endingPage "176" @default.
- W2057873365 startingPage "167" @default.
- W2057873365 abstract "Changes in autonomic receptor systems (α- and β-adrenoceptors and muscarinic receptors) were compared in the aging and failing human heart. In both settings responsiveness of β-adrenoceptors and all other receptor systems that evoke their effects via cyclic AMP accumulation was diminished. Muscarinic receptor function, on the other hand, was decreased in the aging, but unchanged in the failing heart; in contrast, G protein-coupled receptor kinase activity was increased in the failing, but unchanged in the aging heart. α-Adrenoceptor function was unchanged or slightly decreased in the failing heart. However, nothing is known on α-adrenoceptor changes in the aging heart. These results indicate that in the failing human heart all autonomic receptor systems appear to be altered in the direction to attenuate β-adrenoceptor responses to sympathetic (over)stimulation while in the aging human heart autonomic receptor systems appear to be altered in a direction that protects the heart against too pronounced reduction in β-adrenoceptor responsiveness." @default.
- W2057873365 created "2016-06-24" @default.
- W2057873365 creator A5016939659 @default.
- W2057873365 creator A5063355903 @default.
- W2057873365 date "2004-10-01" @default.
- W2057873365 modified "2023-10-16" @default.
- W2057873365 title "Autonomic receptor systems in the failing and aging human heart: similarities and differences" @default.
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