FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2057874039> ?p ?o ?g. }

• W2057874039 endingPage "856" @default.
• W2057874039 startingPage "853" @default.
• W2057874039 abstract "1. ‘Chelation therapy’ with EDTA is being frequently used in patients with cardiovascular disease, despite limited objective evidence of effectiveness. Depressed nitric oxide (•NO)-related endothelial function accompanies atherosclerosis, and even the vascular risk factors alone, and is improved by numerous interventions that also improve prognosis in vascular disease. 2. The aim of the present study was to determine the influence of chelation therapy with EDTA alone and EDTA in combination with B vitamins on endothelial function. 3. After a control series of saline infusions, we examined the effects of a series of EDTA infusions (1.5 g, 10 times over 6 weeks) in eight subjects with coronary artery disease. In addition, because EDTA is commonly supplemented by other components, particularly B group vitamins, we subsequently examined the effect of a similar series of vitamin-supplemented EDTA infusions. 4. Forearm blood flow (FBF) was assessed by plethysmography and graded intrabrachial infusions of the endothelium-dependent vasodilator acetylcholine (ACh) and the endothelium- independent dilator sodium nitroprusside (SNP). 5. There was no difference in vasodilation to either drug after EDTA alone compared with the control periods, but the response to ACh was augmented after combined therapy (P < 0.03, ANOVA). The latter was accompanied by a small but consistent mean (±SEM) fall in plasma homocysteine of 1.6±0.5 μmol/L (P < 0.05). 6. The selective increase in the vasodilator response to ACh after therapy with EDTA and several B group vitamins indicates that NO-related endothelial function was improved. The absence of response to EDTA alone suggests that the supplementary vitamins were necessary for this benefit, which may have been related to the accompanying decrease in plasma homocysteine. These results, along with the current interest in the possible cardioprotective effects of vitamins and the increasing administration of ‘chelation therapy’, call for more definitive studies on these aspects of ‘alternative medicine’." @default.
• W2057874039 created "2016-06-24" @default.
• W2057874039 creator A5000241042 @default.
• W2057874039 creator A5005602035 @default.
• W2057874039 creator A5007209236 @default.
• W2057874039 creator A5026126938 @default.
• W2057874039 creator A5042026749 @default.
• W2057874039 creator A5051410566 @default.
• W2057874039 date "1999-11-04" @default.
• W2057874039 modified "2023-10-17" @default.
• W2057874039 title "EFFECTS OF CHELATION WITH EDTA AND VITAMIN B THERAPY ON NITRIC OXIDE-RELATED ENDOTHELIAL VASODILATOR FUNCTION" @default.
• W2057874039 cites W1966292733 @default.
• W2057874039 cites W1971296888 @default.
• W2057874039 cites W1975357252 @default.
• W2057874039 cites W1993170061 @default.
• W2057874039 cites W2010202776 @default.
• W2057874039 cites W2019468493 @default.
• W2057874039 cites W2024568090 @default.
• W2057874039 cites W2049348584 @default.
• W2057874039 cites W2052055930 @default.
• W2057874039 cites W2062235285 @default.
• W2057874039 cites W2063281374 @default.
• W2057874039 cites W2069538362 @default.
• W2057874039 cites W2085728170 @default.
• W2057874039 cites W2091181219 @default.
• W2057874039 cites W2102909775 @default.
• W2057874039 cites W2109804940 @default.
• W2057874039 cites W2124378690 @default.
• W2057874039 cites W2127651267 @default.
• W2057874039 cites W2133236056 @default.
• W2057874039 cites W2156158060 @default.
• W2057874039 cites W2169939099 @default.
• W2057874039 cites W3025878700 @default.
• W2057874039 doi "https://doi.org/10.1046/j.1440-1681.1999.03156.x" @default.
• W2057874039 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10561804" @default.
• W2057874039 hasPublicationYear "1999" @default.
• W2057874039 type Work @default.
• W2057874039 sameAs 2057874039 @default.
• W2057874039 citedByCount "18" @default.
• W2057874039 countsByYear W20578740392012 @default.
• W2057874039 countsByYear W20578740392016 @default.
• W2057874039 countsByYear W20578740392017 @default.
• W2057874039 countsByYear W20578740392018 @default.
• W2057874039 countsByYear W20578740392019 @default.
• W2057874039 countsByYear W20578740392020 @default.
• W2057874039 countsByYear W20578740392022 @default.
• W2057874039 crossrefType "journal-article" @default.
• W2057874039 hasAuthorship W2057874039A5000241042 @default.
• W2057874039 hasAuthorship W2057874039A5005602035 @default.
• W2057874039 hasAuthorship W2057874039A5007209236 @default.
• W2057874039 hasAuthorship W2057874039A5026126938 @default.
• W2057874039 hasAuthorship W2057874039A5042026749 @default.
• W2057874039 hasAuthorship W2057874039A5051410566 @default.
• W2057874039 hasConcept C120770815 @default.
• W2057874039 hasConcept C126322002 @default.
• W2057874039 hasConcept C134018914 @default.
• W2057874039 hasConcept C2776992346 @default.
• W2057874039 hasConcept C2777032099 @default.
• W2057874039 hasConcept C2779610285 @default.
• W2057874039 hasConcept C2780972559 @default.
• W2057874039 hasConcept C519581460 @default.
• W2057874039 hasConcept C71924100 @default.
• W2057874039 hasConcept C98274493 @default.
• W2057874039 hasConceptScore W2057874039C120770815 @default.
• W2057874039 hasConceptScore W2057874039C126322002 @default.
• W2057874039 hasConceptScore W2057874039C134018914 @default.
• W2057874039 hasConceptScore W2057874039C2776992346 @default.
• W2057874039 hasConceptScore W2057874039C2777032099 @default.
• W2057874039 hasConceptScore W2057874039C2779610285 @default.
• W2057874039 hasConceptScore W2057874039C2780972559 @default.
• W2057874039 hasConceptScore W2057874039C519581460 @default.
• W2057874039 hasConceptScore W2057874039C71924100 @default.
• W2057874039 hasConceptScore W2057874039C98274493 @default.
• W2057874039 hasIssue "11" @default.
• W2057874039 hasLocation W20578740391 @default.
• W2057874039 hasLocation W20578740392 @default.
• W2057874039 hasOpenAccess W2057874039 @default.
• W2057874039 hasPrimaryLocation W20578740391 @default.
• W2057874039 hasRelatedWork W1992741767 @default.
• W2057874039 hasRelatedWork W2013028364 @default.
• W2057874039 hasRelatedWork W2053452541 @default.
• W2057874039 hasRelatedWork W2099266904 @default.
• W2057874039 hasRelatedWork W2140231157 @default.
• W2057874039 hasRelatedWork W2167769224 @default.
• W2057874039 hasRelatedWork W2258735827 @default.
• W2057874039 hasRelatedWork W2548052441 @default.
• W2057874039 hasRelatedWork W2565635511 @default.
• W2057874039 hasRelatedWork W2977425909 @default.
• W2057874039 hasVolume "26" @default.
• W2057874039 isParatext "false" @default.
• W2057874039 isRetracted "false" @default.
• W2057874039 magId "2057874039" @default.
• W2057874039 workType "article" @default.