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- W2057874055 abstract "The density of beta-adrenergic receptors has been determined on membranes prepared from lymphocytes of normal human volunteers. Long-term administration of propranolol resulted in an increase in the density of receptors, whereas administration of the agonists ephedrine and terbutaline elicited a marked decrease in the density of receptors. These changes may explain the delayed side effects observed when propranolol administration is abruptly discontinued and the decreased efficacy that occurs during long-term administration of an agonist. In other experiments, pindolol, an antagonist with intrinsic sympathomimetic activity, was administered to normal subjects. A marked decrease in the density of receptors occurred within 1 day of administering pindolol. This effect persisted beyond the time at which pindolol administration was discontinued." @default.
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- W2057874055 date "1983-01-01" @default.
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- W2057874055 title "Effects of Drugs on β-Adrenergic Receptors on Human Lymphocytes" @default.
- W2057874055 doi "https://doi.org/10.1097/00005344-198300051-00010" @default.
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