FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2057884178> ?p ?o ?g. }

• W2057884178 endingPage "4802" @default.
• W2057884178 startingPage "4796" @default.
• W2057884178 abstract "Zanamivir (ZA) is a potent anti-influenza drug, but it cannot be administrated orally because of the hydrophilic carboxylate and guanidinium groups. Guanidino-oseltamivir (GO) is another effective neuraminidase inhibitor with polar guanidinium group under physiological conditions. The ester prodrugs ZA–HNAP (5) and GO–HNAP (6) were prepared to incorporate a 1-hydroxy-2-naphthoic (HNAP) moiety to attain good lipophilicity in the intramolecular ion-pairing forms. ZA–HNAP resumed high anti-influenza activity (EC50 = 48 nM), in cell-based anti-influenza assays, by releasing zanamivir along with nontoxic HNAP. Under similar conditions, the hydrolysis of the GO–HNAP ester was too sluggish to show the desired anti-influenza activity." @default.
• W2057884178 created "2016-06-24" @default.
• W2057884178 creator A5014070689 @default.
• W2057884178 creator A5037293443 @default.
• W2057884178 creator A5056155365 @default.
• W2057884178 creator A5056753239 @default.
• W2057884178 creator A5060679249 @default.
• W2057884178 creator A5069913342 @default.
• W2057884178 date "2011-08-01" @default.
• W2057884178 modified "2023-10-14" @default.
• W2057884178 title "Intramolecular ion-pair prodrugs of zanamivir and guanidino-oseltamivir" @default.
• W2057884178 cites W1969943225 @default.
• W2057884178 cites W1970045005 @default.
• W2057884178 cites W1971310126 @default.
• W2057884178 cites W1987929665 @default.
• W2057884178 cites W1988044361 @default.
• W2057884178 cites W1998620534 @default.
• W2057884178 cites W2003926950 @default.
• W2057884178 cites W2015518146 @default.
• W2057884178 cites W2020585508 @default.
• W2057884178 cites W2024437558 @default.
• W2057884178 cites W2028849261 @default.
• W2057884178 cites W2037397270 @default.
• W2057884178 cites W2046745698 @default.
• W2057884178 cites W2055986785 @default.
• W2057884178 cites W2057487557 @default.
• W2057884178 cites W2063587286 @default.
• W2057884178 cites W2082647108 @default.
• W2057884178 cites W2086035737 @default.
• W2057884178 cites W2098027131 @default.
• W2057884178 cites W2102182534 @default.
• W2057884178 cites W2107346688 @default.
• W2057884178 cites W2113619184 @default.
• W2057884178 cites W2116117316 @default.
• W2057884178 cites W2126383827 @default.
• W2057884178 cites W2134886116 @default.
• W2057884178 cites W2256756668 @default.
• W2057884178 doi "https://doi.org/10.1016/j.bmc.2011.06.080" @default.
• W2057884178 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21778065" @default.
• W2057884178 hasPublicationYear "2011" @default.
• W2057884178 type Work @default.
• W2057884178 sameAs 2057884178 @default.
• W2057884178 citedByCount "22" @default.
• W2057884178 countsByYear W20578841782012 @default.
• W2057884178 countsByYear W20578841782013 @default.
• W2057884178 countsByYear W20578841782014 @default.
• W2057884178 countsByYear W20578841782015 @default.
• W2057884178 countsByYear W20578841782016 @default.
• W2057884178 countsByYear W20578841782018 @default.
• W2057884178 countsByYear W20578841782019 @default.
• W2057884178 countsByYear W20578841782020 @default.
• W2057884178 countsByYear W20578841782023 @default.
• W2057884178 crossrefType "journal-article" @default.
• W2057884178 hasAuthorship W2057884178A5014070689 @default.
• W2057884178 hasAuthorship W2057884178A5037293443 @default.
• W2057884178 hasAuthorship W2057884178A5056155365 @default.
• W2057884178 hasAuthorship W2057884178A5056753239 @default.
• W2057884178 hasAuthorship W2057884178A5060679249 @default.
• W2057884178 hasAuthorship W2057884178A5069913342 @default.
• W2057884178 hasBestOaLocation W20578841782 @default.
• W2057884178 hasConcept C108215921 @default.
• W2057884178 hasConcept C142724271 @default.
• W2057884178 hasConcept C185592680 @default.
• W2057884178 hasConcept C201399114 @default.
• W2057884178 hasConcept C2776568683 @default.
• W2057884178 hasConcept C2777538117 @default.
• W2057884178 hasConcept C2778074193 @default.
• W2057884178 hasConcept C2779134260 @default.
• W2057884178 hasConcept C2780374985 @default.
• W2057884178 hasConcept C2781442963 @default.
• W2057884178 hasConcept C3008058167 @default.
• W2057884178 hasConcept C524204448 @default.
• W2057884178 hasConcept C55493867 @default.
• W2057884178 hasConcept C71240020 @default.
• W2057884178 hasConcept C71924100 @default.
• W2057884178 hasConcept C75079739 @default.
• W2057884178 hasConcept C94412978 @default.
• W2057884178 hasConceptScore W2057884178C108215921 @default.
• W2057884178 hasConceptScore W2057884178C142724271 @default.
• W2057884178 hasConceptScore W2057884178C185592680 @default.
• W2057884178 hasConceptScore W2057884178C201399114 @default.
• W2057884178 hasConceptScore W2057884178C2776568683 @default.
• W2057884178 hasConceptScore W2057884178C2777538117 @default.
• W2057884178 hasConceptScore W2057884178C2778074193 @default.
• W2057884178 hasConceptScore W2057884178C2779134260 @default.
• W2057884178 hasConceptScore W2057884178C2780374985 @default.
• W2057884178 hasConceptScore W2057884178C2781442963 @default.
• W2057884178 hasConceptScore W2057884178C3008058167 @default.
• W2057884178 hasConceptScore W2057884178C524204448 @default.
• W2057884178 hasConceptScore W2057884178C55493867 @default.
• W2057884178 hasConceptScore W2057884178C71240020 @default.
• W2057884178 hasConceptScore W2057884178C71924100 @default.
• W2057884178 hasConceptScore W2057884178C75079739 @default.
• W2057884178 hasConceptScore W2057884178C94412978 @default.
• W2057884178 hasIssue "16" @default.
• W2057884178 hasLocation W20578841781 @default.
• W2057884178 hasLocation W20578841782 @default.
• W2057884178 hasLocation W20578841783 @default.

• next