Matches in SemOpenAlex for { <https://semopenalex.org/work/W2057886477> ?p ?o ?g. }
Showing items 1 to 87 of
87
with 100 items per page.
- W2057886477 endingPage "57" @default.
- W2057886477 startingPage "49" @default.
- W2057886477 abstract "The adrenergic nerve function and contractile responses of the densely innervated caudal artery of the 8-week streptozotocin (SZ) (65 mg/kg i.p.) diabetic rat were investigated. Segments of this artery were removed from diabetic and control rats, placed in Krebs-filled tissue baths (37 degrees C) and isometric tension recorded. Contractile responses to sympathetic nerve activation by electrical stimulation and to cumulative concentrations of norepinephrine (NE) and tyramine were recorded. In order to determine NE content, the NE was extracted from the caudal artery, isolated by adsorption chromatography, and quantified by HPLC with electrochemical detection. NE accumulation and release were also studied by quantifying the amount of tritiated NE [( 3H]NE) and its metabolites in extracts of the tissue or incubation medium. The responses of the caudal artery of SZ diabetic rats to electrical stimulation (4-16 Hz) and to tyramine (1 X 10(-5)-1 X 10(-4) M) were significantly less than those of arteries from control rats and the NE content reduced by 41%, while sensitivity to NE was unchanged. Diabetic arteries also accumulated and released more [3H]NE than did arteries from control rats. These results establish that neurovascular function of the isolated caudal artery of the 8-week SZ diabetic rat is abnormal and suggest that problems in the ability of adrenergic nerves to store and release NE may contribute to this dysfunction. Such changes may play a role in the cardiovascular disturbances associated with diabetic autonomic neuropathy." @default.
- W2057886477 created "2016-06-24" @default.
- W2057886477 creator A5026992073 @default.
- W2057886477 creator A5032982363 @default.
- W2057886477 creator A5039826111 @default.
- W2057886477 creator A5067445865 @default.
- W2057886477 date "1988-11-01" @default.
- W2057886477 modified "2023-10-14" @default.
- W2057886477 title "Adrenergic nerve function and contractile activity of the caudal artery of the streptozotocin diabetic rat" @default.
- W2057886477 cites W1979314367 @default.
- W2057886477 cites W1982602193 @default.
- W2057886477 cites W1996424575 @default.
- W2057886477 cites W2003919682 @default.
- W2057886477 cites W2032134560 @default.
- W2057886477 cites W2056513499 @default.
- W2057886477 cites W2057934386 @default.
- W2057886477 cites W2167800628 @default.
- W2057886477 cites W2336604548 @default.
- W2057886477 cites W4242527798 @default.
- W2057886477 cites W4245744048 @default.
- W2057886477 cites W2025035311 @default.
- W2057886477 doi "https://doi.org/10.1016/0165-1838(88)90007-0" @default.
- W2057886477 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2976072" @default.
- W2057886477 hasPublicationYear "1988" @default.
- W2057886477 type Work @default.
- W2057886477 sameAs 2057886477 @default.
- W2057886477 citedByCount "20" @default.
- W2057886477 countsByYear W20578864772012 @default.
- W2057886477 countsByYear W20578864772013 @default.
- W2057886477 countsByYear W20578864772018 @default.
- W2057886477 crossrefType "journal-article" @default.
- W2057886477 hasAuthorship W2057886477A5026992073 @default.
- W2057886477 hasAuthorship W2057886477A5032982363 @default.
- W2057886477 hasAuthorship W2057886477A5039826111 @default.
- W2057886477 hasAuthorship W2057886477A5067445865 @default.
- W2057886477 hasConcept C103486182 @default.
- W2057886477 hasConcept C126322002 @default.
- W2057886477 hasConcept C134018914 @default.
- W2057886477 hasConcept C158453852 @default.
- W2057886477 hasConcept C170493617 @default.
- W2057886477 hasConcept C185592680 @default.
- W2057886477 hasConcept C24998067 @default.
- W2057886477 hasConcept C2776077682 @default.
- W2057886477 hasConcept C2776820930 @default.
- W2057886477 hasConcept C2778514916 @default.
- W2057886477 hasConcept C2779178840 @default.
- W2057886477 hasConcept C2779280383 @default.
- W2057886477 hasConcept C513476851 @default.
- W2057886477 hasConcept C555293320 @default.
- W2057886477 hasConcept C71924100 @default.
- W2057886477 hasConceptScore W2057886477C103486182 @default.
- W2057886477 hasConceptScore W2057886477C126322002 @default.
- W2057886477 hasConceptScore W2057886477C134018914 @default.
- W2057886477 hasConceptScore W2057886477C158453852 @default.
- W2057886477 hasConceptScore W2057886477C170493617 @default.
- W2057886477 hasConceptScore W2057886477C185592680 @default.
- W2057886477 hasConceptScore W2057886477C24998067 @default.
- W2057886477 hasConceptScore W2057886477C2776077682 @default.
- W2057886477 hasConceptScore W2057886477C2776820930 @default.
- W2057886477 hasConceptScore W2057886477C2778514916 @default.
- W2057886477 hasConceptScore W2057886477C2779178840 @default.
- W2057886477 hasConceptScore W2057886477C2779280383 @default.
- W2057886477 hasConceptScore W2057886477C513476851 @default.
- W2057886477 hasConceptScore W2057886477C555293320 @default.
- W2057886477 hasConceptScore W2057886477C71924100 @default.
- W2057886477 hasIssue "1" @default.
- W2057886477 hasLocation W20578864771 @default.
- W2057886477 hasLocation W20578864772 @default.
- W2057886477 hasOpenAccess W2057886477 @default.
- W2057886477 hasPrimaryLocation W20578864771 @default.
- W2057886477 hasRelatedWork W1939011572 @default.
- W2057886477 hasRelatedWork W1950756293 @default.
- W2057886477 hasRelatedWork W1995246277 @default.
- W2057886477 hasRelatedWork W2040169485 @default.
- W2057886477 hasRelatedWork W2266753634 @default.
- W2057886477 hasRelatedWork W2270330560 @default.
- W2057886477 hasRelatedWork W2322391976 @default.
- W2057886477 hasRelatedWork W1931411812 @default.
- W2057886477 hasRelatedWork W2211271135 @default.
- W2057886477 hasRelatedWork W2269299226 @default.
- W2057886477 hasVolume "25" @default.
- W2057886477 isParatext "false" @default.
- W2057886477 isRetracted "false" @default.
- W2057886477 magId "2057886477" @default.
- W2057886477 workType "article" @default.