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• W2057903726 abstract "The survival times of red blood cells in three men with lead poisoning and in 14 heavily exposed men without clinical symptoms were measured with the aid of 3H-labeled di-isopropylfluorphosphonate. In about half of the subjects, the red cell survival times fell below the normal range. Almost significant (p < 0.05) or significant (p < 0.01) correlations were found between the red cell survival time on the one hand, and the concentration of hemoglobin and lead in the blood, the degree of reticulocytosis, and the concentration of coproporphyrin in the urine, on the other. The radioactivity of the red blood cells declined with time in a linear fashion in each subject; neither could a deviation from linearity be established in the pooled data of all subjects, tested by two independent statistical methods. The linear decline of the disappearance curves for labeled cells suggests that the shortening of the mean survival time of circulating red cells in subjects exposed to lead was not to any significant degree a result of increased random destruction. Lead thus seems to shorten the true life span of most circulating red blood cells." @default.
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• W2057903726 date "1967-11-01" @default.
• W2057903726 modified "2023-10-16" @default.
• W2057903726 title "Nonrandom shortening of red cell survival times in men exposed to lead" @default.
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• W2057903726 doi "https://doi.org/10.1016/0013-9351(67)90017-5" @default.
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