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- W2057903963 abstract "Thiourea derivatives (1-38) were synthesized and evaluated for their urease inhibition potential. The synthetic compounds showed a varying degree of in vitro urease inhibition with IC50 values 5.53 ± 0.02-91.50 ± 0.08 μM, most of which are superior to the standard thiourea (IC₅₀ = 21.00 ± 0.11 μM). In order to ensure the mode of inhibition of these compounds, the kinetic study of the most active compounds has been carried out. Most of these inhibitors were found to be mixed-type of inhibitors, except compounds 13 and 30 which were competitive, while compound 19 was identified as non-competitive inhibitor with Ki values between 8.6 and 19.29 μM." @default.
- W2057903963 created "2016-06-24" @default.
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- W2057903963 date "2014-03-01" @default.
- W2057903963 modified "2023-10-14" @default.
- W2057903963 title "Synthesis and in vitro urease inhibitory activity of N,N′-disubstituted thioureas" @default.
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- W2057903963 doi "https://doi.org/10.1016/j.ejmech.2014.01.001" @default.
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