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• W2057904305 abstract "A Phase I, double-blind, randomized, crossover study in healthy males (N=106) was conducted between March 21, 2004, and May 17, 2004, to determine the magnitude and duration of the hemodynamic interaction of avanafil (a phosphodiesterase type-5 inhibitor for treating males with erectile dysfunction) when coadministered with glyceryl trinitrate (NTG) compared with sildenafil and placebo. Subjects received avanafil (200 mg), sildenafil (100 mg), and placebo (on separate days) via the oral route followed by NTG (0.4 mg) 12, 8, 4, 1, or 0.5 hours post-dose via the sublingual route. Blood pressure (BP) and heart rate (HR) were assessed at defined intervals." @default.
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• W2057904305 date "2013-01-01" @default.
• W2057904305 modified "2023-10-18" @default.
• W2057904305 title "Hemodynamic effect of avanafil and glyceryl trinitrate coadministration" @default.
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• W2057904305 doi "https://doi.org/10.7573/dic.212248" @default.
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